Publicaciones científicas
- [INGENIERÍA DE TEJIDOS CARDIACA]
- [TERAPIA CELULAR ADOPTIVA]
- [INGENIERÍA BIOMÉDICA]
- [MEDICINA REGENERATIVA]
3D printed bioresorbable scaffolds for articular cartilage tissue engineering: A comparative study between neat Polycaprolactone (PCL) and Poly (lactide-b-ethylene glycol) (PLA-PEG) block copolymer
Uzuri Urtaza 1 , Olatz Guaresti 2 , Izar Gorroñogoitia 3 , Ana Zubiarrain-Laserna 3 , Emma Muiños-López 4 , Froilán Granero-Moltó 5 , J M Lamo de Espinosa 4 , Tania López-Martínez 6 , Manuel M Mazo Vega 7 , Felipe Prosper 8 , Ane Miren Zaldua 3 , Jon Anakabe 3
Abstract
This work identifies and describes different material-scaffold geometry combinations for Cartilage Tissue Engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned and printed using bioresorbable PCL (polycaprolactone) and PLA PEG- (poly(lactide-b-ethylene) block copolymer).
Medical grades of both polymers were 3D printed with FFF technology within an ISO 7 classified cleanroom. Resulting scaffolds were then optically, mechanically and biologically tested.
Results indicated that a few material-scaffold geometry combinations present potential for excellent cell viability as well as for an enhance of the chondrogenic properties of the cells, hence suggesting their suitability for CTE applications.
CITA DEL ARTÍCULO Biomed Mater. 2022 Jun 14. doi: 10.1088/1748-605X/ac78b7
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