Scientific publications

The Role of Circulating Biomarkers in Peripheral Arterial Disease

Mar 30, 2021 | Magazine: International Journal of Molecular Sciences

Goren Saenz-Pipaon, Esther Martinez-Aguilar, Josune Orbe, Arantxa González Miqueo, Leopoldo Fernandez-Alonso, Jose Antonio Paramo, Carmen Roncal


Abstract

Peripheral arterial disease (PAD) of the lower extremities is a chronic illness predominantly of atherosclerotic aetiology, associated to traditional cardiovascular (CV) risk factors. It is one of the most prevalent CV conditions worldwide in subjects >65 years, estimated to increase greatly with the aging of the population, becoming a severe socioeconomic problem in the future. The narrowing and thrombotic occlusion of the lower limb arteries impairs the walking function as the disease progresses, increasing the risk of CV events (myocardial infarction and stroke), amputation and death.

Despite its poor prognosis, PAD patients are scarcely identified until the disease is advanced, highlighting the need for reliable biomarkers for PAD patient stratification, that might also contribute to define more personalized medical treatments. In this review, we will discuss the usefulness of inflammatory molecules, matrix metalloproteinases (MMPs), and cardiac damage markers, as well as novel components of the liquid biopsy, extracellular vesicles (EVs), and non-coding RNAs for lower limb PAD identification, stratification, and outcome assessment. We will also explore the potential of machine learning methods to build prediction models to refine PAD assessment. In this line, the usefulness of multimarker approaches to evaluate this complex multifactorial disease will be also discussed.

CITATION  Int J Mol Sci. 2021 Mar 30;22(7):3601. doi: 10.3390/ijms22073601.

Our authors

Silueta investigador
Goren Saenz de Pipaón
Josune Orbe Lopategui
Carmen Roncal Mancho