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Genomic diagnostics staff is needed for the research project: "Genomic precision medicine in lymphoid neoplasms (PREGENLIF) PMP21/00015", and funded by Instituto de Salud Carlos III and funded by the European Union - NextGenerationEU, Recovery, Transformation and Resilience Plan. A full time contract is offered, with funding for 3 years.

The selected person will be in charge of:

- Collaborate collaboratively in the design of the genomic clinical report and subsequently the preparation of reports from genomic data collected after sequencing of included cases.

- Participate in the evaluation of the clinical impact on prognosis and therapeutic prediction of the genomic alterations found.

- To participate in the coordination of the incorporation of patients that guarantee the selection criteria, coming from the working groups belonging to the PETHEMA, GELLC, GELTAMO and GEM consortia.

- Manage the correct shipment and reception of samples, distributed in different autonomous communities, to the reference centers participating in the Project.

Requirements:

- To be in position of the title of doctor (PhD).

- Experience in clinical genetics and elaboration of genetic reports.

- Able to plan and organize the work in time.

- Able to work in a team.

- Able to solve problems.

- Able to work without supervision.

Interested persons should send their cv and a letter of interest including previous experience and motivations to:

Óscar González Moreno
ogonmor@unav.es
Tel. +34 948 194 700 ext 811047

We need to hire a Laboratory Technician for the research project: "Genomic precision medicine in lymphoid neoplasms (PREGENLIF) PMP21/00015", and funded by Instituto de Salud Carlos III and funded by the European Union - NextGenerationEU, Recovery Plan Transformation and Resilience. A full time contract is offered, with funding for 3 years.

The selected person will be in charge of:

- The selection, processing and preparation of samples included to the project.

- Performing the extraction of nucleic acids from the samples and the preparation of shipments to the sequencing center.

- Additionally, he/she will be in charge of collecting the Informed Consents, the biobanking of each sample, as well as the creation of the database of the collected cases, with the corresponding clinical, biological and imaging data.

Requirements:

- To be in position with a degree of Senior Laboratory Technician (FP). Other qualifications, such as undergraduate or graduate degree, will not be considered.

- Experience in sample processing and database maintenance.

- Experience in nucleic acid extraction from clinical samples.

- Able to plan and organize work over time.

- Able to work in a team environment.

- Able to solve problems.

- Able to work without supervision.

Interested persons should send their cv and a letter of interest including previous experience and motivations to:

Oscar Gonzalez Moreno
ogonmor@unav.es
Tel. +34 948 194 700 ext 811047

Purpose: In the framework of the R+D+i Projects in "strategic lines" CARTsol, Project PLEC2022-009217 funded by MCIN/AEI /10.13039/501100011033 and by the European Union NextGenerationEU/ PRTR, the recruitment of a Ph.D. is needed.
Functions: The main functions of the person to be hired will be:
- Design and generation of human CARs targeting breast cancer tumor antigens.
- Generation of CAR-T cells (human and murine) by lentiviral and retroviral transduction.
- Encapsulation of CAR-T cells in biodegradable porous capsules.
- In vitro studies to study the viability and effector functions of the encapsulated CAR-T cells.
- In vitro and in vivo pharmacokinetic studies to study the controlled release of CAR-T cells.
- Generation of orthotopic immunocompetent breast cancer and xenograft models to study the antitumor efficacy of encapsulated CAR-T cells.
- Adoptive cell therapy studies to study the antitumor efficacy of encapsulated CAR-T cells.
- Screening of adjuvant factors that through co-encapsulation with CAR-T cells enhance their antitumor action.
Minimum Requirements: 
- PhD in Molecular and Cellular Biology, Applied Medicine and Biomedicine, or similar.
- Solid experience in:
   - Cell culture 
   - Flow cytometry 
   - Molecular biology
   - Animal models of disease.
-Certificate and accreditation of competency to work with laboratory animals (rodents).
-Two letters of recommendation from thesis supervisors and/or postdoctoral positions.

Will be considered: 
-Proficiency in English
-Having published articles in scientific journals that certify having experience in the minimum requirements demanded.

Those interested should send their CV to the following e-mail address to mshervas@unav.es

Publication date: December 21st 2022

A postdoctoral position is offered at the OnTarget Group led by professor Silve Vicent at Cima University of Navarra. The project is aimed at the identification of new oncogenic vulnerabilities and therapeutic strategies for the treatment of tumors with KRAS mutations (Erice et al, Clin Cancer Res 2023; Lasheras-Otero, J Inves Dermat 2022; Vallejo et al, J Hepatology 2021; Valencia et al, J Clin Invest 2020; Vallejo et al, Nat Comms 2017; Roman et al, Mol Cancer 2018; Roman et al, Cancer Res 2018) and will provide opportunities for interaction with other groups (internally, nationally and internationally) as well as industry partners.

The project will require, among other tasks, generation of new 3D tumor organoid and syngeneic models using the CRISPR/Cas9 genome editing technology, development of CRISPR/Cas9 screens, functional characterization of new elements within the KRAS network, testing of novel combinatorial therapies involving targeted therapies and immune checkpoint inhibitors, and characterization of the mechanism of action for nominated genes and/or drug combinations using high-throughput (RNAseq, scRNAseq, proteomics and/or metabolomics) and focused (qPCR, WB, IF and live imaging) approaches. 

Candidate’s requirements:
- PhD in biological or biomedical sciences. Preference will be given to candidates with a title obtained in the last 12 months.
- Self-motivated, resilient, autonomous person with team work skills and ability to work in various projects.
- Background in Cancer Biology and/or Immunotherapy.
- Training in animal work is a plus.
- Publication record to compete for additional fellowship applications (e.g. Marie Curie actions, Juan de la Cierva, …) is mandatory (at least one first-author publication).
Interested applicants should send a cover letter describing past experience and interests to: silvevicent@unav.es

About Cima

CIMA is the biomedical research center of the Clínica Universidad de Navarra (https://cima.cun.es/en). Our scientific objective is to address current clinical problems and to propose the most effective treatment for each patient. CIMA is committed to excellence in translational research, based on novel biological knowledge and aimed at finding therapeutic solutions to patients' needs. 
We are a reference in cancer, immunotherapy, heart and liver diseases, and gene therapy research. With our academic status, we work on a non-profit basis to reinvest the surpluses in our research and to fulfill our mission of service to patients and society. To transfer the results of basic research to clinical application, CIMA’s Translation and Transfer unit establishes collaborations with biotechnology and pharmaceutical companies to facilitate the arrival of scientific discoveries to the bedside.

Purpose of the position: 
Performance of doctoral thesis in the cardiovascular diseases group.

Qualifications required:
Bachelor's and master's degree in the field of experimental and health sciences. 

Title of the project:
Identification of new molecular targets involved in the development of adverse cardiac remodeling and therapeutic application of anti-fibrotic nanoparticles.

Project director: Dr. Beatriz Pelacho

Number of positions offered: 1

Funding entity: FIMA

Required documentation: Updated curriculum vitae

Submission of applications and more information: bpelacho@unav.es

Application forms available at: https://www.unav.edu/investigacion/escuela-de-doctorado/financiacion-y-ayudas

Characteristics of the aid:
It will be in accordance with the provisions of the Convocatoria Marco de Ayudas Adscritas a Proyectos de Investigación para contratos predoctorales (Framework Call for Aid for Research Projects for pre-doctoral contracts).

Date of publication: November 30, 2022

Looking for a highly motivated biomedical engineer, to join my Cima Universidad de Navarra team, to participate in a research project recently funded by the Government of Navarra (POLIFARMA-3D).

This project deals with the use of 3D organ-on-chip models and microfluidic devices to study the dynamics of poly-bacterial infections. 

A Computational Biologist or Bioinformatician position is offered to work at the Adoptive Cell Therapy Laboratory of the Hemato-Oncology Program of the CIMA Universidad de Navarra in Pamplona (Spain). The 3-year position is funded by the European Union through the EIC Pathfinder programme and offers the opportunity to exploit deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell engineering to clinical application. The work will be in permanent collaboration with an interactive international team of basic and translational researchers.

The successful candidate will:
• Participate in the planning, processing, analysis and interpretation of next generation sequencing experiments (scRNA-seq, sc ATAC-seq, CITE-seq, etc.).
• Participate in the development of data analysis workflows and pipelines for high throughput “omics” data, as well as implementation of software tools for multiomic analysis.
• Collaborate in multiple projects, having the possibility to carry on a personal research project.
• Active participation on manuscript preparations and project submission.

Desired qualifications:
• University degree or postgraduate training in computational biology & bioinformatics.
• Experience in the data processing and statistical analysis of high-throughput genomic data.
• Knowledge of informatics tools and visualization/data mining packages and an aptitude for optimally adapting them to specific problems.
• Knowledge of programming environment (R/Bioconductor, Matlab) and programming languages (Perl, Python, Java...).
• Good organizational, communication and interpersonal skills.


Interested applicants should send a cover letter describing past experience and interests as well as their CV including references to:

Oscar Gonzalez Moreno
ogonmor@unav.es
Tel. +34948194700 ext 811047

 

A PhD position is offered to work at the Adoptive Cell Therapy Laboratory of the Hemato-Oncology Program of the Cima Universidad de Navarra in Pamplona (Spain). The position is funded by a Josep Carreras Foundation project and offers the opportunity to advance in the field of CAR-T cells in multiple myeloma through the optimization of this therapy using genetically heterogeneous murine models. The successful candidate is expected to perform original research developing and characterizing improved and optimized CAR-T cells that will be evaluated in vivo in preclinical mouse models. The work will be in permanent collaboration with an interactive international team of basic and translational researchers.

We are seeking for highly motivated candidates with leadership, initiative and the capacity to work as part of a team. The successful applicants must hold a BSs and MSC at the time of recruitment, or equivalent studies allowing access to the Doctoral School. Experience in the field of immunotherapy and cancer immunology/hematology will be highly considered. 

Interested applicants should send a cover letter describing past experience and interests as well as their CV including at least two references to:

Oscar Gonzalez Moreno
ogonmor@unav.es
Tel. +34948194700 ext 811047

 

The lab of Xabier Aranguren, Regenerative Medicine Program, at Cima University of Navarra, is seeking a highly motivated postdoc candidate to work on a research project focused on the molecular and epigenetic bases of human naïve iPS cells chimeric potential.
Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. bioRxiv 2022.03.06.482812; doi: https://doi.org/10.1101/2022.03.06.482812

Funding

Offer within the framework of the BIOHEART project financed by the Government of Navarra. Project reference: 0011-1411-2022-000092
 

Job Information
- Application closing date: 31st July 2022.
-Employment start date: 1st of August 2022.
-Contract duration: 2 years and 5-month, with possibility of renovation.
Institution: Cima University of Navarra.

 

Background and project
Blastocyst complementation is a promising approach to generate organs in vivo from stem cells, using an animal recipient. The group has been working in this field for the last 8 years using mouse and rat animal models and cells, as well as human naïve iPS cells.
The project consists of the development of different strategies to increase human iPSC chimeric potential, and the generation of interspecific chimeras.
The selected candidate will have the opportunity to work in a young team in an excellent scientific environment and will have access to the state-of-the-art equipment and facilities dedicated to transgenesis. He/she will be trained for embryo microinjection.

Your Role:
Contribute to the project performing research to grasp the molecular and epigenetic bases of human naïve iPS cells chimeric potential by developing new strategies to increase cell contribution to interspecies chimerae.
Prepare papers for publication in leading international peer-reviewed journals.
Disseminate findings at conferences and meetings.

Your Profile:
- Holding a PhD diploma.
- A strong research track record in human iPS cells biology.
- Strong motivation.
- Ability to work both independently and as part of a team.
- Organization skills, initiative.
- Clarity in communication.
- Experience with gene editing technologies.
- Experience in transgenesis of mouse/pig models is desired but not required
- Spanish is not a requirement for English speakers.

What we offer:
- A position in a highly visible research project at the frontiers of knowledge in the field of stem cells and xenoorgan generation.
- A well-equipped work environment.
- Participation in courses and conferences.
- Comprehensive training in embryo micromanipulation.

Additional benefits:
- Accident insurance policy.
- Reduction on University training programs fees.
- Familiar allowance for children below 18 and for non-working partner.
- Free access to University sport facilities and library.
- Restaurant ticket, Transport ticket and Daycare ticket for tax discounts.
- Private health insurance policy “Poliza hospitalización platinum plus” from ACUNSA to all employees starting from the second year of contract. This policy can be voluntarily ampliated with discount to “Poliza Confort”. Employees’ children under 17 are given the “Poliza Confort” for free starting from the second year of contract. Discounts on insurance policy for employee spouse and children above 17 are offered.

 

The Institute is located at University of Navarra academic campus close to the center of the city with free bicycle and car parking lot.
 

Town: Pamplona is a highly dynamic and international city of Spain, which attracts a large number of university students and scientists. The city has plenty of bars and restaurants to enjoy the typical Navarra’s gastronomy and social life. The neighborhoods are the ideal destination for nature’s lovers, with woods of rare beauty. The Cantabric coast is 1h away.
 

Contact Information
Xabier Aranguren, Cima University of Navarra, 31008, Pamplona, Spain
Email: xlaranguren@unav.es

Website


Please send your application including a motivation letter, your CV and reference letters from your previous employees.
 

We are seeking a highly motivated Computational scientist to join the Myeloma Research Laboratory at the Cima Universidad de Navarra. The selected candidate will join an international group of scientists that are leaders in the field of translational research in multiple myeloma and other hematological malignancies.


We offer a 3-year contract and a consolidated structure to achieve new outcomes in immunogenomics. The selected candidate will be working in a unique environment of a combined diagnostic and research laboratories. We have state-of-the-art technology and experimental models, together with large datasets of patients with multiomics and clinical data.
 

The successful candidate will: 
• Participate in the planning, processing, analysis and interpretation of multidimensional flow cytometry and next generation sequencing (RNA-seq, ChIP-seq, ATAC-seq, HI-C, single cell RNA-seq, etc.) data.
• Participate in the development of data analysis workflows and pipelines for high throughput “omics” data. 
• Collaborate in multiple projects and leadership in personal research projects.
• Implement and customize existing software tools for multiomic analysis. 
• Supervise and teach junior members of the lab.  
• Active participation in manuscripts, grants and abstracts.
Required qualifications:
• University degree and postgraduate training in computational biology & bioinformatics. 
• Experience in the data processing and statistical analysis of high-throughput data.
• Knowledge of informatics tools and visualization/data mining packages and an aptitude for optimally adapting them to specific problems.
• Knowledge of statistical programming environment (R/Bioconductor, Matlab) and programming languages (Perl, Python, Java…).
• Proficiency in written and spoken English.
• Good organizational, communication and interpersonal skills.
Desirable qualifications:
• PhD degree and postgraduate training in computational biology & bioinformatics.
• Familiarity with Linux/Unix environment and high-performance computing (clusters).
• Experience in interdisciplinary collaborations on bioinformatics services.
• Familiarity with contemporary basic biology and biomedical research topics.
Interested applicants should send a cover letter describing experience and interests as well as their CV including references to:
Bruno Paiva
bpaiva@unav.es
T + 34 948 194 700 ext 811038

 

Research group: The candidate will join the Laboratory of Atherothrombosis at the Program of Cardiovascular Diseases, a multidisciplinary research group including clinical and basic scientists. The group has an extensive experience in vascular pathologies and thrombosis, always combining clinical and basic research. The supervisor, Dr. Carmen Roncal, has contributed to more than 40 research articles, and the group has been involved in more than 30 national and international research projects. 

Research project: Peripheral artery disease (PAD) is one of the most prevalent cardiovascular (CV) condition globally with >200 million cases. Among PAD patients, those with concomitant diabetes mellitus progress faster, and more frequently advance to critical limb ischemia, boosting their risk of thrombosis, amputation and death (2 to 3-fold) compared to non-diabetic PAD subjects. Diabetes-induced endothelial dysfunction and platelet activation play a critical role in atherothrombosis, and thus the study of the molecular changes induced by hyperglycemia on those cell types might be useful to identify novel diagnosis and prognosis biomarkers in diabetic PAD patients. Nevertheless, the inaccessibility and diffuse nature of endothelial cells hinders the possibility of studying them. In this regard, Extracellular vesicles (EVs), nanometric lipidic spheres released into blood by most cell types carrying nucleic acids, proteins and lipids from parental cells, offer a unique opportunity to analyse the content of parental cells in the bloodstream. 

The aim of this translational projects is to identify endothelial and platelet associated molecular patterns in diabetic PAD patients that will provide novel CV risk biomarkers and therapeutic targets for this high cardiovascular risk subgroup. To address our purpose, we will isolate and sequence endothelial and platelet derived EVs from diabetic and non-diabetic PAD patient, select 3 to 5 differentially expressed genes, and measure their blood levels to determine their association with worse outcome in PAD (diabetic and non-diabetic) patients. The regulation of the selected candidates by hyperglycemia will be studied in vitro and in vivo in endothelial cells, and mice models of diabetes and atherosclerosis. Finally, machine learning methods will be applied to calculate algorithms that might further improve the diagnosis and risk stratification of diabetic PAD patients.

Candidate description: We look for a highly motivated Master degree candidate, with excellent records, who is expected to enroll in a PhD programme at the Universidad de Navarra and to apply for PhD funding.

The candidate will join a research group focused in translational studies, that benefits from the experience of clinicians as well as molecular and cellular biologist with broad experience in the physiopathology of atherosclerosis and thrombosis. The candidate will receive training in cellular and molecular biology, always maintaining the focus on the translation nature of the project. He/she will participate in weekly laboratory meetings, and the advances of the project will be presented in lab seminars and national and international congresses. The candidate will be encouraged for a short-term stage abroad.

A bachelor and a master in Biomedical Sciences (e.g. biology, biochemistry, pharmacy, medicine, biomedicine…) is required. The fellow must be fluent in English (both oral and written). Previous experience in histology, cellular and molecular biology, and statistics is recommended but not essential.

Interested applicants should send a cover letter describing past experience and interests as well as their CV to: Carmen Roncal Mancho, croncalm@unav.es

A postdoctoral position supported by “la Caixa Research” is available in the group headed by Maite Huarte at Cima Universidad de Navarra, in Pamplona, Spain.

  • The candidate will work on a collaborative project with a multidisciplinary team of molecular, structural, computational and biophysics experts to understand the role of lncRNAs in the response to replicative stress in cancer cells.
  • We are looking for highly motivated and talented individuals, preferentially with previous expertise in molecular, RNA, chromatin and cancer biology.
  • Knowledge of the analysis and interpretation of genomic data are desirable.

The position offers the opportunity for professional growth by working in an interactive and dynamic international environment of translational and basic science research.
 

Interested applicants should send a cover letter describing their past experience and interests, as well as their CV (including Educational Information and scores as well as references) to: Maite Huarte, maitehuarte@unav.es. T + 34 948 194 700 ext 814000

A PhD position supported by “Agencia Estatal de Investigación” will open soon to work in the group headed by Maite Huarte at Cima Universidad de Navarra, in Pamplona, Spain.
Our lab aims to understand how RNA in general and lncRNA in particular affect chromatin replication and gene regulation in cancer. By working in a stimulating environment with an international team of translational and basic researchers, the position offers the opportunity of being trained in the latest technologies for the study of non-coding genes, ranging from molecular and cellular biology to epigenetics and functional genomics.
Please visit our lab webpage.

  • We are looking for candidates with an interest in applying to this PhD call, likely to open sometime after the summer, bearing in mind that the call will impose formal requirement for applicants. Salaries and other conditions will be defined.
  • We look for highly motivated individuals with a science/master’s degree.
  • Some experience in molecular and cellular biology is highly recommended and background in biology positively valued.
  • Excellent knowledge of the English language is required.

Interested applicants should send a cover letter describing their past experience and interests as well as their CV (including Educational Information and scores as well as references) to: Maite Huarte, maitehuarte@unav.es. T + 34 948 194 700 ext 814000

PI: Susana Ravassa

Chronic heart failure is a heterogeneous syndrome, the end result of diverse pathophysiological mechanisms and different histocellular alterations.

In order to design personalized therapeutic strategies aimed at correcting the predominant alterations in each patient, it is necessary to have precise biomarkers that allow early diagnosis, better risk stratification in patients and monitoring of the effects of therapy. 

Since obtaining endomyocardial biopsies is not feasible on a large scale, circulating and imaging biomarkers are a useful tool for the analysis of large patient populations. In recent years we have defined a panel of biomarkers of myocardial remodeling that includes markers of fibrosis (PICP and CITP:MMP-1), cardiomyocyte damage and stress (NT-proBNP and hs-TnT) and inflammation (IL-18, sST-2, galectin-3).

Similarly, advances in cardiac magnetic resonance have allowed the development of new parameters to assess microvascular alterations and diffuse myocardial fibrosis.

This project focuses on analyzing the diagnostic and therapeutic usefulness of the panel of biomarkers of myocardial remodeling and identifying new molecular biomarkers to define molecular profiles corresponding to the different phenotypes of patients with chronic heart failure.

Objectives

  1. To establish a profile of circulating and cardiac imaging biomarkers that reflect the different aspects of myocardial remodeling. Biomarkers already identified will be combined with new biomarkers under development, derived from proteomic studies and characterization of non-coding RNAs.
  2. To assess the diagnostic and prognostic utility of the panel of biomarkers of myocardial remodeling in patients with chronic heart failure of different etiologies and different associated pathologies (atrial fibrillation, chronic kidney disease...).
  3. To analyze the usefulness of the myocardial remodeling biomarker panel for monitoring the effects of therapy in patients with chronic heart failure and associated pathologies.
  4. To use the myocardial remodeling biomarker panel to detect cardiovascular sequelae in patients with cardiotoxicity induced by chemotherapeutic agents or in patients infected with Sars-CoV-2.

We are seeking for a creative, ambitious and highly motivated Postdoc candidate to join a fully funded project within the Hematology-Oncology Program at CIMA Universidad de Navarra.

The candidate will join a highly collaborative environment with the opportunity to apply cutting-edge genomic technologies on the field of Hematology Oncology. The work will be in permanent collaboration with an interactive international team of basic and translational researchers.

The successful candidate will:

  • Work in a unique team of experts in Multiple Myeloma

  • Participate in high impact projects involving next generation sequencing experiments for the study of gene regulation and epigenetics (RNA-seq, ChIP-seq, ATAC-seq, HI-C, single cell RNA-seq, etc.), flow cytometry and cellular and molecular studies.

  • Analyze and integrate cancer genomic data.

  • Participate in the development of data analysis workflows and pipelines for high throughput “omics” data.

  • Collaborate in multiple projects, having the possibility to carry on a personal research project.

  • Collaborate with the development of any bioinformatic necessary tools to accomplish goals.

  • Be involved in a project that moves from early basic research towards clinical translation and from massive studies to single molecules

  • Co-supervise PhD and Master students

  • Participate in the oral presentation of all project findings and abstracts including participation in periodic project status meetings and presentation of final project deliverables

Required qualifications:

  • PhD training in molecular and cellular biology with skills in NGS and flow cytometry techniques and/or Multiple Myeloma.

  • Experience in sample processing, cellular and molecular biology.

  • Animal handling experience.

  • Excellent interpersonal skills (project management, English and communication –oral and written-, motivation and resilience, organization, creativity, initiative, vision, connectedness, teamwork abilities…).

  • Experience with multidisciplinary approaches and bioinformatics are highly desirable. Applicants are encouraged to apply for competitive fellowship awards. Salary will be commensurate with qualifications and experience.

Interested applicants should send a cover letter describing past experience and interests as well as their CV including references to:

Oscar González
ogonmor@unav.es
T + 34 948 194 700 ext 811047

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The Cima Universidad de Navarra is committed to the best professionals as a differentiating element and guarantor of this service. Its professionals come from different disciplines work at Cima: researchers, engineers, laboratory technicians, administrative and management personnel.... 

The most common professional profiles are the following:

  • Researcher
  • Technician

If you think that your educational and professional background may fit with any of the above-mentioned professional profiles or with any other of the Cima departments, do not hesitate to send us your curriculum vitae.

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