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We are seeking a highly motivated Computational scientist to join the Myeloma Research Laboratory at the Cima Universidad de Navarra. The selected candidate will join an international group of scientists that are leaders in the field of translational research in multiple myeloma and other hematological malignancies.


We offer a 3-year contract and a consolidated structure to achieve new outcomes in immunogenomics. The selected candidate will be working in a unique environment of a combined diagnostic and research laboratories. We have state-of-the-art technology and experimental models, together with large datasets of patients with multiomics and clinical data.
 

The successful candidate will: 
• Participate in the planning, processing, analysis and interpretation of multidimensional flow cytometry and next generation sequencing (RNA-seq, ChIP-seq, ATAC-seq, HI-C, single cell RNA-seq, etc.) data.
• Participate in the development of data analysis workflows and pipelines for high throughput “omics” data. 
• Collaborate in multiple projects and leadership in personal research projects.
• Implement and customize existing software tools for multiomic analysis. 
• Supervise and teach junior members of the lab.  
• Active participation in manuscripts, grants and abstracts.
Required qualifications:
• University degree and postgraduate training in computational biology & bioinformatics. 
• Experience in the data processing and statistical analysis of high-throughput data.
• Knowledge of informatics tools and visualization/data mining packages and an aptitude for optimally adapting them to specific problems.
• Knowledge of statistical programming environment (R/Bioconductor, Matlab) and programming languages (Perl, Python, Java…).
• Proficiency in written and spoken English.
• Good organizational, communication and interpersonal skills.
Desirable qualifications:
• PhD degree and postgraduate training in computational biology & bioinformatics.
• Familiarity with Linux/Unix environment and high-performance computing (clusters).
• Experience in interdisciplinary collaborations on bioinformatics services.
• Familiarity with contemporary basic biology and biomedical research topics.
Interested applicants should send a cover letter describing experience and interests as well as their CV including references to:
Bruno Paiva
bpaiva@unav.es
T + 34 948 194 700 ext 811038

 

A postdoctoral position is offered at the Oncogenes and Metastasis laboratory which hosts the research groups of professor Fernando Lecanda and Silve Vicent at the Center for Applied Medical Research (Cima University of Navarra). This is an industry-funded project aimed at the refined characterization of new mouse lung cancer models for Immuno-Oncology research will provide opportunities for interaction with other groups (internally, nationally and internationally) as well as industry sponsors. The project builds on the consolidated expertise in Cancer Biology, Tumor Microenvironment and Targeted Therapies (Ruiz-Fernandez de Cordoba et al, Cancer Discov, 2022; Ortiz-Espinosa et al, Cancer Letters 2022; Vallejo et al, J Hepatology 2021; Valencia et al, JCI 2020; Roman et al, Cancer Res., 2018; Ajona et al, AJRCCM, 2018; Vallejo et al, Nat Comms 2017)
 

The project will require, among other tasks: the characterization new syngeneic models using the CRISPR/Cas9 genome editing technology, deep genomic exome sequencing, and single cell analysis of the tumor microenvironment using multiparametric flow cytometry and single cell RNA sequencing. It is anticipated that this research will lead to new combined Immune Therapies with targeted therapies and standard-of-care chemotherapies.
 

Candidate’s requirements:
- PhD in biological or biomedical sciences. 
- Excellent communications skills (English proficient level).
- Self-motivated, resilient, autonomous person with team work skills and ability to work in a fast-paced environment.
- Background in Cancer Biology and/or Immunotherapy (although preference will be given to candidates with immunotherapy background)
- Training in animal work is a must.
- Publication record to compete for additional fellowship applications (e.g. Marie Curie actions, Juan de la Cierva, …) is preferable (at least one first-author publication).

 

The postdoctoral position is initially funded for 1 year and could be extended for two additional years upon satisfactory performance. The appointment will start in May/June 2022. Applications will be accepted starting March 10th through May 31st (or until the position is filled if that occurs later).
 

Interested applicants should send a cover letter describing past experience and interests, as well as their CV including at least two references to: flecanda@unav.es; silvevicent@unav.es
 

About Cima:

Cima is the biomedical research center of the Clínica Universidad de Navarra (https://cima.cun.es/en). Our scientific objective is to address current clinical problems and to propose the most effective treatment for each patient. Cima is committed to excellence in translational research, based on novel biological knowledge and aimed at finding therapeutic solutions to patients' needs. 
We are a reference in cancer, immunotherapy, heart and liver diseases, and gene therapy research. With our academic status, we work on a non-profit basis to reinvest the surpluses in our research and to fulfill our mission of service to patients and society. To transfer the results of basic research to clinical application, Cima’s Translation and Transfer Unit establishes collaborations with biotechnology and pharmaceutical companies to facilitate the arrival of scientific discoveries to the bedside.

We offer a PhD position at Clinica Universidad de Navarra’s neurology department

Project description
The work focuses on the analysis and modeling of brain connectivity in Parkinson's disease and essential tremor using functional magnetic resonance imaging and/or diffusion-weighted imaging, including the potential development of predictive models based on machine learning.

Requeriments
Bachelor's degree in physics, mathematics or related engineering and preferably with a master's degree in neuroscience or basic knowledge in this field.

Contact: smartore@unav.es

We offer a postdoctoral position working as Laboratory manager, at the Cima Universidad de Navarra, Pamplona Spain. Laboratory of Dr. Maria C Rodriguez Oroz.

Project Description
Our laboratory is focused on the study of the origin and pathophysiology of Parkinson’s disease using a rat model of progressive parkinsonism induced by the overexpression of mutated alpha-synuclein in the substantia nigra pars compacta (SNc). Our ultimate aim is to develop new therapies that could counterbalance the key factors involved in the degenerative process.

The project is focused on the study of the mechanisms involved in the beginning and progression of the dopaminergic degeneration focused on the functional and structural changes in the synapses. We use different approaches: molecular (isolation of synaptosomes and proteomics), immunochemistry, electron microscopy, and confocal microscopy studies as well as synaptic plasticity assessment by flow cytometry (FASS-LTP). The position will carry out advanced multiphoton studies in awake behaving rats. 

Eligibility criteria
•       The applicant must have a doctoral degree in neuroscience, biomedicine, cellular, molecular biology, or a related discipline and a broad postdoctoral experience in models of parkinsonism that qualifies him/her for this position. 
•       The applicant must have experience in stereotaxic surgery in rodents, behavioral assessments, histological techniques and other basic skills
•    The applicant must have experience with multiphoton imaging and fluorescence lifetime microscopy in neuroscience.
•     Experience with flow cytometry is an advantage. 
•    The applicant must have good communication skills in written and oral English, a solid track of scientific publication and research projects.
•     The candidate should be able to work independently and interactively in a team setting, be motivated and responsible, and have a great work capacity and enthusiasm for research. 
•    The applicant should contribute to project management, provision of guidance to junior researchers as well as undergraduate and graduate students.

Contact: Cristina Canciani, canciani@unav.es

AECC Lab funded contract to join the research group lead by Miguel F Sanmamed MD, PhD at Clínica Universidad de Navarra and Center for Applied Medical Research (CIMA) at Pamplona.

This is a lab manager position for someone who is interested to join an emerging lab with a special focus in cancer immunotherapy translational research.

Qualification required: PhD in biology, biochemistry, biomedicine, biotechnology or similar.

Desirable experience: Experimental animal certification and with an expertise in multiparametric flow-cytometry.

 

Desirable skills: Good leadership skills and ability to work as part of a team; creative problem solving and high degree of autonomy.

Target start date: February 2022

Interested candidates should send a short letter describing their previous experience and current short-term and long-term career goals accompanied by their CV to Miguel F Sanmamed: msanmamed@unav.es

Purpose of the position: PhD thesis in co-direction between the Computational Biology and Molecular Therapies programs at Cima. It will focus on the development of computational models based on graph neural networks (and graph Machine Learning in general) for drug design through protein structure inference.

Project title: "ABIRES: Elucidating response to Abiraterone in metastatic castrate resistant prostate cancer"

Project directors: Mikel Hernaez y Antonio Pineda

Required Degree: Degree in Telecommunications Engineering/Mathematics/Physics or similar. Master's degree in Biotechnology, Computational Methods, Machine Learning or similar is required.

Number of positions available: 1

Contract amount (gross amount): 16.392,26 €.

Funding entity: U.S. Department of Defense.

Place and deadline for submitting the application: 

The information to formalize the applications for participation in this Grant Program can be found at the following link.

Applications will be sent by email to investigacion@unav.es within 15 days from the publication of this specific call.

Characteristics of the aid and other conditions of the Program:

It will be in accordance with the provisions of the Framework Call for grants attached to research projects for pre-doctoral contracts included in the following link.

For further information, we are at your disposal at the following e-mail address: investigacion@unav.es
or at telephone number 948425600 (802247).

Date of publication: 18/01/2022

Research group: The candidate will join the Laboratory of Atherothrombosis at the Program of Cardiovascular Diseases, a multidisciplinary research group including clinical and basic scientists. The group has an extensive experience in vascular pathologies and thrombosis, always combining clinical and basic research. The supervisor, Dr. Carmen Roncal, has contributed to more than 40 research articles, and the group has been involved in more than 30 national and international research projects. 

Research project: Peripheral artery disease (PAD) is one of the most prevalent cardiovascular (CV) condition globally with >200 million cases. Among PAD patients, those with concomitant diabetes mellitus progress faster, and more frequently advance to critical limb ischemia, boosting their risk of thrombosis, amputation and death (2 to 3-fold) compared to non-diabetic PAD subjects. Diabetes-induced endothelial dysfunction and platelet activation play a critical role in atherothrombosis, and thus the study of the molecular changes induced by hyperglycemia on those cell types might be useful to identify novel diagnosis and prognosis biomarkers in diabetic PAD patients. Nevertheless, the inaccessibility and diffuse nature of endothelial cells hinders the possibility of studying them. In this regard, Extracellular vesicles (EVs), nanometric lipidic spheres released into blood by most cell types carrying nucleic acids, proteins and lipids from parental cells, offer a unique opportunity to analyse the content of parental cells in the bloodstream. 

The aim of this translational projects is to identify endothelial and platelet associated molecular patterns in diabetic PAD patients that will provide novel CV risk biomarkers and therapeutic targets for this high cardiovascular risk subgroup. To address our purpose, we will isolate and sequence endothelial and platelet derived EVs from diabetic and non-diabetic PAD patient, select 3 to 5 differentially expressed genes, and measure their blood levels to determine their association with worse outcome in PAD (diabetic and non-diabetic) patients. The regulation of the selected candidates by hyperglycemia will be studied in vitro and in vivo in endothelial cells, and mice models of diabetes and atherosclerosis. Finally, machine learning methods will be applied to calculate algorithms that might further improve the diagnosis and risk stratification of diabetic PAD patients.

Candidate description: We look for a highly motivated Master degree candidate, with excellent records, who is expected to enroll in a PhD programme at the Universidad de Navarra and to apply for PhD funding.

The candidate will join a research group focused in translational studies, that benefits from the experience of clinicians as well as molecular and cellular biologist with broad experience in the physiopathology of atherosclerosis and thrombosis. The candidate will receive training in cellular and molecular biology, always maintaining the focus on the translation nature of the project. He/she will participate in weekly laboratory meetings, and the advances of the project will be presented in lab seminars and national and international congresses. The candidate will be encouraged for a short-term stage abroad.

A bachelor and a master in Biomedical Sciences (e.g. biology, biochemistry, pharmacy, medicine, biomedicine…) is required. The fellow must be fluent in English (both oral and written). Previous experience in histology, cellular and molecular biology, and statistics is recommended but not essential.

Interested applicants should send a cover letter describing past experience and interests as well as their CV to: Carmen Roncal Mancho, croncalm@unav.es

Date of publication: 02/20/2022

Project title: Understanding How the Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death.

Project director:  Dr. José A. Martínez-Climent

Purpose of the position: A position is offered in the Laboratory of Lymphoproliferative Syndromes of the Department of Hemato-Oncology at Cima Universidad de Navarra for the development of doctoral studies and doctoral thesis.
Required Degree: Degree in Pharmacy or Biology, and Master's degree in a cancer biology-related field.

Number of positions available: 1

Contract amount: 16.392,26 € (gross amount)

Funding entity: Cima Universidad de Navarra

Place and deadline for submitting the application: 

The information to formalize the applications for participation in this Grant Program can be found at the following link.

Applications will be sent by email to investigacion@unav.es within 15 days from the publication of this specific call.

Characteristics of the aid and other conditions of the Program:

It will be in accordance with the provisions of the Framework Call for grants attached to research projects for pre-doctoral contracts included in the following link.

For further information, we are at your disposal at the following e-mail address: investigacion@unav.es
or at telephone number 948425600 (802247).

Date of publication: 09/02/2021

Project title: ABIRES: Elucidating response to Abiraterone in metastatic castrate resistant prostate cancer

Project directors:  Prof. Mikel Hernaez and Liewei Wang

Purpose of the position: Development of the doctoral thesis in the context of the PROMOTE project, in collaboration with the Mayo Clinic, USA. The candidate will develop computational tools using artificial intelligence to elucidate transcriptomic changes between responders and non-responders to the drug ABIRATERONE in patients with metastatic castration-resistant prostate cancer.
Required Degree: Advanced degree in Pharmacy/Biochemistry/Telecommunications/Mathematics/ or similar. Master's degree in computational methods/Machine Learning or similar is required.

Number of positions available: 1

Contract amount: 20,775,88 € (including SS payable by the entity and insurance).

Funding entity: US Department of Defense

Place and deadline for submitting the application: 

The information to formalize the applications for participation in this Grant Program can be found at the following link.

Applications will be sent by email to investigacion@unav.es within 15 days from the publication of this specific call.

Characteristics of the aid and other conditions of the Program:

It will be in accordance with the provisions of the Framework Call for grants attached to research projects for pre-doctoral contracts included in the following link.

For further information, we are at your disposal at the following e-mail address: investigacion@unav.es
or at telephone number 948425600 (802247).

Date of publication: 08/16/2021

Our laboratory at Cima Universidad de Navarra, in Spain, is recruiting a highly motivated postdoc to work on long noncoding RNAs and cancer genomics.

The position is funded by the Government of Navarra and offers the opportunity to work in a collaborative project with a multidisciplinary team of clinical, translational, and basic researchers.   

  • Previous experience in RNA, genomics, molecular biology, and biochemistry, is required.
  • The familiarity with the preparation of libraries for next-generation sequencing will be very positively valued.
  • Experience with the processing of human samples and knowledge of bioinformatics will also be considered. 

Interested applicants should send their CV including references to Puri Fortes, pfortes@unav.es T + 34 948 194 700 ext 814025 and/or Maite Huarte, maitehuarte@unav.es. T + 34 948 194 700 ext 814000

A postdoctoral position supported by “la Caixa Research” is available in the group headed by Maite Huarte at Cima Universidad de Navarra, in Pamplona, Spain.

  • The candidate will work on a collaborative project with a multidisciplinary team of molecular, structural, computational and biophysics experts to understand the role of lncRNAs in the response to replicative stress in cancer cells.
  • We are looking for highly motivated and talented individuals, preferentially with previous expertise in molecular, RNA, chromatin and cancer biology.
  • Knowledge of the analysis and interpretation of genomic data are desirable.

The position offers the opportunity for professional growth by working in an interactive and dynamic international environment of translational and basic science research.
 

Interested applicants should send a cover letter describing their past experience and interests, as well as their CV (including Educational Information and scores as well as references) to: Maite Huarte, maitehuarte@unav.es. T + 34 948 194 700 ext 814000

A PhD position supported by “Agencia Estatal de Investigación” will open soon to work in the group headed by Maite Huarte at Cima Universidad de Navarra, in Pamplona, Spain.
Our lab aims to understand how RNA in general and lncRNA in particular affect chromatin replication and gene regulation in cancer. By working in a stimulating environment with an international team of translational and basic researchers, the position offers the opportunity of being trained in the latest technologies for the study of non-coding genes, ranging from molecular and cellular biology to epigenetics and functional genomics.
Please visit our lab webpage.

  • We are looking for candidates with an interest in applying to this PhD call, likely to open sometime after the summer, bearing in mind that the call will impose formal requirement for applicants. Salaries and other conditions will be defined.
  • We look for highly motivated individuals with a science/master’s degree.
  • Some experience in molecular and cellular biology is highly recommended and background in biology positively valued.
  • Excellent knowledge of the English language is required.

Interested applicants should send a cover letter describing their past experience and interests as well as their CV (including Educational Information and scores as well as references) to: Maite Huarte, maitehuarte@unav.es. T + 34 948 194 700 ext 814000

PI: Begoña Salazar

Diffuse myocardial fibrosis, or exaggerated accumulation of collagen in the myocardium, plays a key role in the development and progression of chronic heart failure. The enzymatic systems involved in the processing of collagen fibers emerge as key mechanisms of the process.

In this regard, 2 relevant systems have recently been identified in the axis of the formation of mature collagen fibers: 1) carboxy-terminal procollagen proteinase (PCP) with its enhancer PCPE-1, which processes the passage from immature procollagen to collagen capable of forming fibers; and 2) lysyl oxidase (LOX), the main enzyme responsible for collagen cross-linking, a process that facilitates the formation of collagen fibers and their deposition.

In recent years it has been shown that myocardial fibrosis is characterized not only by an increase in the quantity of collagen but also by alterations in its quality, such as an increase in the degree of collagen cross-linking (GrE).

This process, as already mentioned, is mainly mediated by enzymes of the lysyl oxidase (LOX) family, and leads to the formation of insoluble collagen fibers that are stiffer and more resistant to degradation.

Patients with a malignant fibrosis phenotype characterized by severe deposition of highly cross-linked collagen fibers have an increased risk of hospitalization or death from cardiovascular causes, as well as an increased risk of complications associated with heart failure such as atrial fibrillation.

Objectives

  1. To deepen in the impact of the different myocardial fibrosis phenotypes in the development and evolution of chronic heart failure and its associated pathologies in patients with heart failure at different stages of evolution and in experimental models (animals and cell cultures).
  2. To analyze the relevance of collagen synthesis (PCP/PCPE-1-LOX) and degradation (matrix metalloproteinases or MMPs) systems in patients with heart failure of different etiology and in models of pressure overload.
  3. To validate the PCP/PCPE-1 system as a therapeutic target for the treatment of myocardial fibrosis in pressure overload models.
  4. To assess the impact of GrE and increased extracellular matrix stiffness on cardiac cell behavior.
  5. To identify new molecular mediators and/or biomarkers involved in the development of diffuse myocardial fibrosis.

PI: Susana Ravassa

Chronic heart failure is a heterogeneous syndrome, the end result of diverse pathophysiological mechanisms and different histocellular alterations.

In order to design personalized therapeutic strategies aimed at correcting the predominant alterations in each patient, it is necessary to have precise biomarkers that allow early diagnosis, better risk stratification in patients and monitoring of the effects of therapy. 

Since obtaining endomyocardial biopsies is not feasible on a large scale, circulating and imaging biomarkers are a useful tool for the analysis of large patient populations. In recent years we have defined a panel of biomarkers of myocardial remodeling that includes markers of fibrosis (PICP and CITP:MMP-1), cardiomyocyte damage and stress (NT-proBNP and hs-TnT) and inflammation (IL-18, sST-2, galectin-3).

Similarly, advances in cardiac magnetic resonance have allowed the development of new parameters to assess microvascular alterations and diffuse myocardial fibrosis.

This project focuses on analyzing the diagnostic and therapeutic usefulness of the panel of biomarkers of myocardial remodeling and identifying new molecular biomarkers to define molecular profiles corresponding to the different phenotypes of patients with chronic heart failure.

Objectives

  1. To establish a profile of circulating and cardiac imaging biomarkers that reflect the different aspects of myocardial remodeling. Biomarkers already identified will be combined with new biomarkers under development, derived from proteomic studies and characterization of non-coding RNAs.
  2. To assess the diagnostic and prognostic utility of the panel of biomarkers of myocardial remodeling in patients with chronic heart failure of different etiologies and different associated pathologies (atrial fibrillation, chronic kidney disease...).
  3. To analyze the usefulness of the myocardial remodeling biomarker panel for monitoring the effects of therapy in patients with chronic heart failure and associated pathologies.
  4. To use the myocardial remodeling biomarker panel to detect cardiovascular sequelae in patients with cardiotoxicity induced by chemotherapeutic agents or in patients infected with Sars-CoV-2.

We are seeking for a creative, ambitious and highly motivated Postdoc candidate to join a fully funded project within the Hematology-Oncology Program at CIMA Universidad de Navarra.

The candidate will join a highly collaborative environment with the opportunity to apply cutting-edge genomic technologies on the field of Hematology Oncology. The work will be in permanent collaboration with an interactive international team of basic and translational researchers.

The successful candidate will:

  • Work in a unique team of experts in Multiple Myeloma

  • Participate in high impact projects involving next generation sequencing experiments for the study of gene regulation and epigenetics (RNA-seq, ChIP-seq, ATAC-seq, HI-C, single cell RNA-seq, etc.), flow cytometry and cellular and molecular studies.

  • Analyze and integrate cancer genomic data.

  • Participate in the development of data analysis workflows and pipelines for high throughput “omics” data.

  • Collaborate in multiple projects, having the possibility to carry on a personal research project.

  • Collaborate with the development of any bioinformatic necessary tools to accomplish goals.

  • Be involved in a project that moves from early basic research towards clinical translation and from massive studies to single molecules

  • Co-supervise PhD and Master students

  • Participate in the oral presentation of all project findings and abstracts including participation in periodic project status meetings and presentation of final project deliverables

Required qualifications:

  • PhD training in molecular and cellular biology with skills in NGS and flow cytometry techniques and/or Multiple Myeloma.

  • Experience in sample processing, cellular and molecular biology.

  • Animal handling experience.

  • Excellent interpersonal skills (project management, English and communication –oral and written-, motivation and resilience, organization, creativity, initiative, vision, connectedness, teamwork abilities…).

  • Experience with multidisciplinary approaches and bioinformatics are highly desirable. Applicants are encouraged to apply for competitive fellowship awards. Salary will be commensurate with qualifications and experience.

Interested applicants should send a cover letter describing past experience and interests as well as their CV including references to:

Oscar González
ogonmor@unav.es
T + 34 948 194 700 ext 811047

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The Cima Universidad de Navarra is committed to the best professionals as a differentiating element and guarantor of this service. Its professionals come from different disciplines work at Cima: researchers, engineers, laboratory technicians, administrative and management personnel.... 

The most common professional profiles are the following:

  • Researcher
  • Technician

If you think that your educational and professional background may fit with any of the above-mentioned professional profiles or with any other of the Cima departments, do not hesitate to send us your curriculum vitae.

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