Publicaciones científicas
Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion
Martín I Castillo 1, Villamón E Ribate 1, Calabuig M Muñoz 1, Sanz G Santillana 2, Such E Taboada 2, Mora E Casterá 2, Calasanz M J Abinzano 3, Irigoyen A Barranco 3, Collado R Nieto 4, Vara M Pampliega 5, M L Blanco 6, Álvarez S de Andrés 7, Pérez J de Oteyza 8, Bernal T Del Castillo 9, Granada I Font 10, Jerez A Cayuela 11, M Díez-Campelo 12, Abellán R Sánchez 13, Solano C Vercet 1, Tormo M Díaz 1; Grupo Español de Síndromes Mielodisplásicos (GESMD)
Abstract
Background: In myelodysplastic neoplasms (MDS), the 20q deletion [del(20q)] is a recurrent chromosomal abnormality that it has a high co-occurrence with U2AF1 mutations. Nevertheless, the prognostic impact of U2AF1 in these MDS patients is uncertain and the possible clinical and/or prognostic differences between the mutation type and the mutational burden are also unknown.
Methods: Our study analyzes different molecular variables in 100 MDS patients with isolated del(20q).
Results & conclusions: We describe the high incidence and negative prognostic impact of U2AF1 mutations and other alterations such as in ASXL1 gene to identify prognostic markers that would benefit patients to receive earlier treatment.
Keywords: 20q deletion; U2AF1 mutations; myelodysplastic neoplasms; prognosis; quantitative allele-specific PCR.
CITA DEL ARTÍCULO Cancer Med. 2023 Aug;12(16):16788-16792. doi: 10.1002/cam4.6300. Epub 2023 Jul 5.