In vivo Organ Generation by Stem Cells
"Development of strategies for in vivo organ generation using stem cells."
DR. XABIER ARANGUREN LÓPEZ
Organ transplantation is a very effective life-saving treatment for end-stage organ diseases. Nevertheless, the number of organs available for transplantations is limited, and the waiting lists are ever increasing, recently counting around 150.000 people Europe and 100.00 in USA, leading to a high rate of death for organ failure: only in the European continent, approximately 5.000 people die every year waiting for an organ, with a mortality rates for patients waiting for a heart, liver or lung ranging between 15 and 30%. The necessity to find additional source of organs for transplantation has boosted research on the generation of organs from pluripotent stem cells (PSCs).
We develop new therapeutic alternatives based on the generation of xeno-organs in vivo by blastocyst complementation using pluripotent stem cells. This strategy is based on the microinjection of stem cells into genetically modified embryos, incapable of generating a certain type of organ/cell type. In this way the target organ is formed exclusively from the microinjected stem cells. The group works with mouse and rat embryonic stem cells and human iPS cells, as well as with genetically modified mouse and pig models.
Objectives of the Research Group Organ Generation in vivo using Stem Cells
In vivo organ generation with stem cells
Generation of organs (cardiovascular system)
in a mouse model by blastocyst supplementation.
Isolation and production
of pluripotent stem cells from different species.
Generation of interspecies chimeras: rat-mouse and human-pig.
Mechanisms of the potential
Study of the mechanisms of stem cell chimerism potential.
Generation of humanized organs in pigs.
Generation of transgenic models
Generation of transgenic models in mice and pigs using gene editing tools.
Our research group coordinates the BIOHEART R&D project, a collaborative study of advanced bioengineering to develop cardiac tissue using cardiac stem cells and gene editing technology.
Meet the research team
Scientific activity of the Research Group Organ Generation in vivo by means of Stem Cells
Latest scientific publications
- Generation of heart and vascular system in rodents by blastocyst complementation Nov 13, 2023 | Magazine: Developmental Cell
- Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures Jan 10, 2023 | Magazine: Stem Cell Reports
- Circulating Tumor Cells for the Staging of Patients With Newly Diagnosed Transplant-Eligible Multiple Myeloma Sep 20, 2022 | Magazine: Journal of Clinical Oncology
- One-Step In Vitro Generation of ETV2-Null Pig Embryos Jul 18, 2022 | Magazine: Animals