Scientific publications
- [LUNGSEARCH: LUNG CANCER SCREENING, EARLY DETECTION, BIOMARKERS AND NEW THERAPEUTIC TARGETS ]
- [SOLID TUMOR]
Lung cancer screening using low-dose CT and FDG-PET in liver transplant recipients
Meylin Caballeros Lam 1, Paula Pujols 2, Ana Ezponda Casajús 3, Fernando Guillén Valderrama 4, María José García Velloso 5, Alejandra Wyss 6, Loreto García Del Barrio 3, Javier Larrache Latasa 3, Jesús Pueyo Villoslada 3, María Dolores Lozano Escario 7, Juan P de-Torres 8, Ana Belén Alcaide Ocaña 8, Aránzazu Campo Ezquibela 8, Luis Seijo Maceiras 9, Luis Montuenga Badía 10, Javier Zulueta 11, Mercedes Iñarrairaegui Bastarrica 12, Ignacio Herrero Santos 12, Gorka Bastarrika Alemañ 3
Abstract
To address the feasibility of implementing a lung cancer screening program in liver transplant recipients (LTR) targeted to detect early-stage lung cancer one hundred twenty-four LTR (89% male, 59.8+/-8.8 y old), who entered the lung cancer screening program at our hospital were reviewed. The results of the diagnostic algorithm using low-dose CT and F-18-fluorodeoxyglycose positron emission tomography (FDG-PET) were analyzed. Lung cancer was detected in 12 LTR (9.7%), most of which corresponded to the non-small cell subtype. Two of the 12 lung cancers were detected in the baseline study (prevalence of 1.6%), whereas 10 patients were diagnosed with lung cancer in the follow-up (incidence of 8.1%). Considering all cancers, 10 of 12 (83.3%) were diagnosed at stage I, one cancer was diagnosed at stage IIIA, and another one at stage IV. The sensitivity, specificity, diagnostic accuracy, and positive and negative predictive values of F-18-fluorodeoxyglycose positron emission tomography to detect malignancy in our cohort were 81.8%,100%, 99.3%, 100%, and 99.3%, respectively. A carefully followed multidisciplinary lung cancer screening algorithm in LTR that includes F-18-fluorodeoxyglycose positron emission tomography and low-dose CT allows lung cancer to be diagnosed at an early stage while reducing unnecessary invasive procedures.
CITA DEL ARTÍCULO Liver Transpl. 2023 Oct 1;29(10):1100-1108. doi: 10.1097/LVT.0000000000000121. Epub 2023 Mar 20.
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