Animal
IMAGE PLATFORM
- Computed Axial Tomography.
- Quantum GX microCT, Perkin.
- Elmer-Computed Axial Tomography. MicroCAT II, Siemens.
- Ultrasound Ultrasound. VEVO 3100 and 770, Visualsonics.
- Bioluminescence and Fluorescence equipment for PHOTONIMAGER animals.
Responsible:
Xabier Morales: xmorales@unav.es
Maider Esparza: maideresparza@unav.es
Phone: +34 948 194 700 Ext. 5021/6004
Vevo 3100®
High-resolution ultrasound for small rodents
Characterization of murine models of heart failure, hypertension and infarction.
Evaluation of systolic and diastolic function by continuous, pulsed and color Doppler, as well as M-mode and 2D and 3D imaging.
Distribution and volumetric evaluation of atheromatous plaques in the aortic arch and carotid arteries by 3D ultrasound.
Guided microinjection of cellular, gene or nanoparticle therapies into the myocardium and abdominal cavity.
Longitudinal study of abdominal tumors by means of 3D ultrasound.
Evaluation of the vasculature accessory to the tumor and the degree of hypoxia by color Doppler and power Doppler.
Evaluation of the vasculature accessory to the tumor and the degree of hypoxia by color Doppler and power Doppler.
Quantum GX®
High-resolution computed tomography for small rodents and clinical specimens
Characterization of murine models of emphysema, fibrosis and respiratory infection by tomographic image evaluation using respiratory gating techniques combined with animal spirometry-based respiratory function tests.
Analysis of histomorphological bone parameters and bone regeneration models based. Quantification of trabecular/cortical volume, degree of mineralization, thickness/space/surface/anisotropy/trabecular connectivity in BALB/c-Rag2 mice inoculated with the MM.1S multiple myeloma line.
Evaluation of bone volume in different phases of calcification after tibial fracture.
Longitudinal study of lung and abdominal tumors based on volumetric measurements using iodinated contrastsLongitudinal study of lung and abdominal tumors based on volumetric measurements using iodinated contrasts.
Characterization of cardiac function in systolic and diastolic phases, as well as ventricular hypertrophy and fibrosis using iodinated contrasts and cardiac gating techniques.
Analysis of parameters applied to the dental clinic and follow-up of orthodontic techniques.
Study of metabolic pathologies such as obesity and diabetes based on subcutaneous and visceral fat measurements.
Characterization of scaffolds for bioengineering and generation of 3D printing files for tissue engineering.
PhotonIMAGER Optima®
Detection, biodistribution and quantification of bioluminescence and fluorescence signals in small rodents, with or without inhalational anesthesia, and cell cultures.
Evaluation of the colonization and biodistribution dynamics of H. Influenza bacteria conjugated with the luxCDABE bioluminescence gene in CD1 mice.
Longitudinal study of in vivo tumor models using bioluminescence. Intratibial implantation of prostate adenocarcinoma tumor cells (LNCaP) in c-Rag2 Balb/c mice.
Longitudinal study of in vivo tumor models using fluorescence. Orthotopic model of hepatocarcinoma of Hep-G2 cells transfected with Texas-Red vector in BALB/cJ mice.
Evaluation by fluorescence and bioluminescence of the biodistribution of tumor cells and/or nanoparticles in both in vivo and ex vivo models. Intracardiac implantation of pancreatic adenocarcinoma cells (PC3) in C57BL/6J mice.
Real-time study of bioluminescence and fluorescence signal kinetics in different regions of interest in particle and/or cell biodistribution models, as well as biochemical reactions.