Publicaciones científicas

Motixafortide and Pembrolizumab Combined to Nanoliposomal Irinotecan, Fluorouracil, and Folinic Acid in Metastatic Pancreatic Cancer: The COMBAT/KEYNOTE-202 Trial

15-sep-2021 | Revista: Clinical Cancer Research

Bruno Bockorny  1   2 , Teresa Macarulla  3 , Valerya Semenisty  4 , Erkut Borazanci  5 , Jaime Feliu  6 , Mariano Ponz-Sarvise  7 , David Gutierrez Abad  8 , Paul Oberstein  9 , Angela Alistar  10 , Andres Muñoz  11 , Ravit Geva  12 , Carmen Guillén-Ponce  13 , Mercedes Salgado Fernandez  14 , Amnon Peled  15   16 , Marya Chaney  17 , Irit Gliko-Kabir  18 , Liron Shemesh-Darvish  18 , Debby Ickowicz  18 , Ella Sorani  18 , Shaul Kadosh  19 , Abi Vainstein-Haras  18 , Manuel Hidalgo  20

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is largely unresponsive to checkpoint inhibitors. Blockade of the CXCR4/CXCL12 axis increases intratumoral trafficking of activated T cells while restraining immunosuppressive elements. This study evaluates dual blockade of CXCR4 and PD1 with chemotherapy in PDAC.

Patients and methods: Multicenter, single-arm, phase II study to evaluate the safety and efficacy of motixafortide and pembrolizumab combined with chemotherapy in patients with de novo metastatic PDAC and disease progression on front-line gemcitabine-based therapy (NCT02826486). Subjects received a priming phase of motixafortide daily on days 1-5, followed by repeated cycles of motixafortide twice a week; pembrolizumab every 3 weeks; and nanoliposomal irinotecan, fluorouracil, and leucovorin every 2 weeks (NAPOLI-1 regimen). The primary objective was objective response rate (ORR). Secondary objectives included overall survival (OS), progression-free survival (PFS), disease control rate (DCR), safety, and tolerability.

Results: A total of 43 patients were enrolled. The ORR according to RECISTv1.1 was 21.1% with confirmed ORR of 13.2%. The DCR was 63.2% with median duration of clinical benefit of 5.7 months. In the intention-to-treat population, median PFS was 3.8 months and median OS was 6.6 months. The triple combination was safe and well tolerated, with toxicity comparable with the NAPOLI-1 regimen. Notably, the incidence of grade 3 or higher neutropenia and infection was 7%, lower than expected for this chemotherapy regimen.

Conclusions: Triple combination of motixafortide, pembrolizumab, and chemotherapy was safe and well tolerated, and showed signs of efficacy in a population with poor prognosis and aggressive disease.

CITA DEL ARTÍCULO  Clin Cancer Res. 2021 Sep 15;27(18):5020-5027. doi: 10.1158/1078-0432.CCR-21-0929.  Epub 2021 Jul 12