Scientific publications

LocoMMotion: a prospective, non-interventional, multinational study of real-life current standards of care in patients with relapsed and/or refractory multiple myeloma. Scientific Publication

May 2, 2022 | Magazine: Leukemia

Maria-Victoria Mateos #  1 , Katja Weisel #  2 , Valerio De Stefano  3 , Hartmut Goldschmidt  4 , Michel Delforge  5 , Mohamad Mohty  6 , Michele Cavo  7 , Ravi Vij  8 , Joanne Lindsey-Hill  9 , Dominik Dytfeld  10 , Emanuele Angelucci  11 , Aurore Perrot  12 , Reuben Benjamin  13 , Niels W C J van de Donk  14 , Enrique M Ocio  15 , Christof Scheid  16 , Francesca Gay  17 , Wilfried Roeloffzen  18 , Paula Rodriguez-Otero  19 , Annemiek Broijl  20 , Anna Potamianou  21 , Caline Sakabedoyan  22 , Maria Semerjian  23 , Sofia Keim  24 , Vadim Strulev  25 , Jordan M Schecter  26 , Martin Vogel  27 , Robert Wapenaar  28 , Tonia Nesheiwat  29 , Jesus San-Miguel  19 , Pieter Sonneveld  20 , Hermann Einsele  30 , Philippe Moreau  31


Abstract

Despite treatment advances, patients with multiple myeloma (MM) often progress through standard drug classes including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and anti-CD38 monoclonal antibodies (mAbs).

LocoMMotion (ClinicalTrials.gov identifier: NCT04035226) is the first prospective study of real-life standard of care (SOC) in triple-class exposed (received at least a PI, IMiD, and anti-CD38 mAb) patients with relapsed/refractory MM (RRMM).

Patients (N = 248; ECOG performance status of 0-1, ≥3 prior lines of therapy or double refractory to a PI and IMiD) were treated with median 4.0 (range, 1-20) cycles of SOC therapy. Overall response rate was 29.8% (95% CI: 24.2-36.0). Median progression-free survival (PFS) and median overall survival (OS) were 4.6 (95% CI: 3.9-5.6) and 12.4 months (95% CI: 10.3-NE).

Treatment-emergent adverse events (TEAEs) were reported in 83.5% of patients (52.8% grade 3/4). Altogether, 107 deaths occurred, due to progressive disease (n = 74), TEAEs (n = 19), and other reasons (n = 14). The 92 varied regimens utilized demonstrate a lack of clear SOC for heavily pretreated, triple-class exposed patients with RRMM in real-world practice and result in poor outcomes. This supports a need for new treatments with novel mechanisms of action.

CITATION  Leukemia. 2022 May;36(5):1371-1376. doi: 10.1038/s41375-022-01531-2. Epub 2022 Mar 24