Cellular Metabolism Service
BIOCHEMICAL ANALYSIS AND CELLULAR METABOLISM PLATFORM
The Cellular Metabolism Service at Cima is oriented to study various aspects of cellular metabolism and bioenergetics.
We have the cutting-edge and exclusive technology offered by the Seahorse XFp extracellular flow analyzer (Agilent). This is the only technology that allows the functional study of cellular bioenergetics in real-time through the analysis of the main energy production pathways of the cell: mitochondrial respiration and glycolysis. This equipment offers the possibility of performing several metabolic assays in a fast and simple way, being of great interest in the study of numerous diseases and therapies in research areas such as cancer, immunology, obesity and diabetes, neurodegeneration, etc.
Our service offers the researcher multiple functional assays in adherent and non-adherent cells, as well as in mitochondria isolated from tissue or cell culture. In addition, it offers the possibility to ask for advice in the choice of the test, in the optimization of the seeding density and drug concentration, and for the interpretation of the results.
Eva Santamaria: email@example.com
Phone: +34 948 194 700 - Ext. 814019
DAY OF SERVICE:
Tuesday and Thursday.
Do you need our services?
If you are interested in knowing our rates and contracting our services, please contact us.
For researchers and companies
Experience and technological capacity to develop different assays for the analysis of multiple parameters of cell metabolism.
Advice to the researcher
We provide researchers with our expertise in the choice of the test, in the design and conduct of the experiment, as well as in the interpretation of the results of metabolic assays.
We innovate in the implementation of new metabolic tests to respond to user demands.
Seahorse XFp Analyzer
Seahorse XF analyzers measure oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells in a multiwell plate. OCR and ECAR rates are key indicators of mitochondrial respiration and glycolysis. These measurements provide a system-level view of cellular metabolic function in cultured cells and ex vivo samples. XF analyzers perform compound addition and mixing, label-free analytical screening, and automatic real-time measurement of OCR and ECAR.
Scientific activity of the
Cellular Metabolism Service
Latest scientific publications
- Identification and experimental validation of druggable epigenetic targets in hepatoblastoma Oct 24, 2023 | Magazine: Journal of Hepatology
- Synplex: In Silico Modeling of the Tumor Microenvironment From Multiplex Images Oct 2, 2023 | Magazine: IEEE Transactions on Medical Imaging
- Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance Sep 20, 2023 | Magazine: Nature Communications
- CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects Aug 18, 2023 | Magazine: Science Advances