Leukemia is an umbrella term for several blood cancers, depending on the type of blood cell that becomes cancerous. The excessive presence of these abnormal cells (leukemic cells) in the bone marrow and blood causes a shortage of healthy blood cells resulting in infections, anemia or easy bleeding. They can also spread to other parts of the body such as the central nervous system and skin.
The most common type of leukemia in adults is acute myeloid leukemia (AML). It is characterized by the rapid and uncontrolled proliferation of myeloblasts (immature white blood cell of the myeloid lineage). It is also known as acute myeloblastic leukemia.
Another common leukemic disease is acute lymphoblastic leukemia, when the bone marrow produces too many lymphocytes (immature white blood cell of the lymphoid lineage).
Despite advances in the biology of this disease, the vast majority of patients still have a poor prognosis and a high percentage relapse.
We dream of curing leukemia.
We delve into the molecular mechanisms involved in the pathogenesis of these diseases to get to the clinic early.
We investigate to identify genetic and epigenetic changes associated with its appearance and evolution.
We study resistance to current therapies and develop new drugs that can be molecular targets in patients.
We work together with researchers and clinicians so that our discoveries reach the patient as soon as possible.
REFERENCES IN HEMATO-ONCOLOGY RESEARCH
Myeloid Pathology Research Group
Reference team in preclinical research on the pathogenesis of myeloid malignancies and the development of innovative strategies for their treatment.