Fatty liver research

Steatosis or fatty liver occurs when fat accumulates in the liver, there is inflammation and liver cells are damaged. Its cause is unknown, but some associated risk factors are obesity, excessive alcohol consumption, insulin resistance, metabolic disorders or having type 2 diabetes. 

It is a disease with a high incidence that can cause liver failure, acute alcoholic hepatitis, cirrhosis or liver cancer. It is also associated with the development of cardiovascular diseases and diabetes.

At the Cima Universidad de Navarra we study steatosis molecularly, genetically and epigenetically. We seek to develop therapeutic strategies to recover liver function, reduce the need for liver transplantation, and prevent the development of liver cancer. Our studies use implemented animal models of the disease and artificial intelligence tools to analyze clinical samples.

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We dream of designing the best hepatoprotective strategies

Treatment options have increased significantly in recent years, but much remains to be discovered.

To deepen the knowledge of molecular, genetic and epigenetic mechanisms in non-alcoholic fatty liver disease.

Develop hepatoprotective strategies to restore liver function, reduce the need for liver transplantation and prevent the development of liver cancer.

We work closely with researchers and clinicians to rapidly translate findings from the laboratory to the patient.

REFERENCES IN TRANSLATIONAL RESEARCH

Hepatic Damage and Carcinogenesis Research Group

Reference team in basic and translational hepatology research with two main objectives:

  • To find new therapeutic strategies to treat steatosis, in addition to other liver diseases, and to prevent the development of liver cancer.
  • To identify and characterize new effective molecular targets for the treatment of liver cancer.

It is part of the Hepatology Program.