Objectives of our research
To deepen the knowledge of the functions of lncRNAs and their molecular mechanisms.
Identify novel lncRNAs and their linkage to cancer.
Contribute to the development of improved cancer therapies and diagnostics based on lncRNAs.
FROM THE LABORATORY TO THE CLINIC
Role of lncRNAs in cancer
Our group has found that lncRNAs have critical functions associated with tumor suppressor or oncogenic genes, such as p53 or MYC, playing a key role in tumor transformation.
We have recently identified a new lncRNA called ALAL-1 that helps lung cancer cells evade the immune system. The blockade of ALAL-1 could drive anti-tumor therapies for these patients.