Hepatic Damage and Carcinogenesis
"We have identified proteins that can protect liver tissue during acute injury and are developing forms of these proteins that can be converted into drugs."
DR. MATÍAS ÁVILA ZARAGOZÁ DIRECTOR. HEPATOLOGY RESEARCH PROGRAM
The Cima Liver Damage and Carcinogenesis Research Group aims to:
- Develop hepatoprotective strategies aimed at recovering liver function and regenerative capacity and leading to reduced mortality in patients with acute liver failure.
- To use these strategies in transplants of organs considered marginal (fatty livers, livers of elderly people or small livers).
- Perform more extensive partial excisions or in organs with compromised regenerative capacity.
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Objectives of the Hepatic Damage
and Carcinogenesis Research Group
Develop hepatoprotective strategies aimed at recovering liver function and regenerative capacity.
To find new therapeutic strategies to treat steatosis and cirrhosis in order to recover liver function.
Identify and characterize effective molecular targets for the treatment of liver cancer.
FROM THE LABORATORY TO THE PATIENT
Cutting-edge translational research
Aware of the impact they have on the population and, consequently, on healthcare costs, the Hepatology Program focuses on understanding the cellular and molecular mechanisms of the hepatic response to acute and chronic injury.
Hepatic lesions
Study of the causes that lead to liver damage and its behavior, which will make it possible to enhance the defense mechanisms and find new treatments.
Liver cirrhosis
When cirrhosis appears, it is irreversible and, if decompensated, the only definitive solution is liver transplantation. Our research is looking for mechanisms to prevent its onset or to slow its progression.
Liver cancer
We do research not only in immunotherapy, but also in the development and knowledge of targeted treatments that aim to identify molecular alterations in liver cells.
Would you like to help us?
Thanks to the generosity of many people, the Cima Universidad de Navarra is a reality that strives to offer therapeutic solutions to achieve personalized medicine for patients.
Meet the research team
Scientific activity of the
Hepatic Damage and Carcinogenesis Research Group
Latest scientific publications
- Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain Mar 3, 2021 | Magazine: Journal of Clinical Medicine
- SPARC inhibition accelerates NAFLD-associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism Feb 28, 2021 | Magazine: Liver International
- Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection Feb 13, 2021 | Magazine: Biomedicine & Pharmacotherapy
- Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis Dec 13, 2020 | Magazine: Cancers (Basel)