"Our goal is to discover new molecular therapies that can address unmet medical needs based on novel targets and/or mechanisms of action."
DR. ANTONIO PINEDA LUCENA DIRECTOR. MOLECULAR THERAPEUTICS RESEARCH PROGRAM
In the Molecular Therapeutics Program at Cima we focus on discovering new molecular therapies that can address unmet medical needs.
Once a new target or mechanism of action (MoA) is discovered, our first objective is to identify chemical probes for in vitro validation. From these chemical probes, we develop new proprietary chemical series that we optimize in order to perform in vivo validation of the new target, both from an efficacy and safety point of view; and to rule out possible associated toxicity.
By validating the target in vivo, we minimize risks and develop pharmacological tools with intellectual property (IP). Thus, for its translation to the clinic, we work with a protected "Markush" formula, which can be explored and optimized to obtain "optimized leads" and identify the most suitable for the clinical phase: pre-clinical candidate.
This working space with intellectual property makes it possible for third parties (e.g. pharmaceutical companies), with more experience and capabilities, to invest in our research and bring the results to the patient, which is our main objective.
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Objectives of the Research Program in Molecular Therapies
in vitro e in vivo
In order to know the efficacy and safety of new targets or mechanisms of action of clinical interest through the use of new molecules.
Design of new molecules for multifactorial optimization and to reach the patient as quickly as possible.
We make it possible for external companies, with capacity and resources, to invest in the project and take it to the patient, which is our main objective.
New molecular therapies
We have different approaches, based on peptides, aptamers and small molecules, which allow us to cover a wide spectrum of alternatives for the development of new therapeutic strategies.
Our research groups
We are looking for pharmacological tools to validate in vivo, in terms of efficacy and safety, new therapeutic targets.
Discovery of small molecules with therapeutic potential.
Development of new aptamers with future therapeutic or diagnostic applications.
Optimization of in vitro chemical probes indicated as therapeutic strategies.
Meet the research team
Scientific activity of the
Molecular Therapeutics Research Program
Latest scientific publications
- Single-Cell RNA-seq Analysis Reveals a Crucial Role for Collagen Triple Helix Repeat Containing 1 (CTHRC1) Cardiac Fibroblasts after Myocardial Infarction Jun 25, 2021 | Magazine: Hepatology
- Endogenous retroelement activation by epigenetic therapy reverses the Warburg effect and elicits mitochondrial-mediated cancer cell death May 1, 2021 | Magazine: Cancer Discovery
- Quantitative Assessment of Dietary (Poly)phenol Intake: A High-Throughput Targeted Metabolomics Method for Blood and Urine Samples Jan 13, 2021 | Magazine: Journal of Agricultural and Food Chemistry
- Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis Dec 13, 2020 | Magazine: Cancers (Basel)