Scientific publications

Adeno-Associated Viral Vectors as Versatile Tools for Neurological Disorders: Focus on Delivery Routes and Therapeutic Perspectives

Mar 23, 2022 | Magazine: Biomedicines

Ana Fajardo-Serrano 1 2 3, Alberto J Rico 1 2 3, Elvira Roda 1 2 3, Adriana Honrubia 1 2 3, Sandra Arrieta 1 2 3, Goiaz Ariznabarreta 1 2 3, Julia Chocarro 1 2 3, Elena Lorenzo-Ramos 1 2 3, Alvaro Pejenaute 1 2 3, Alfonso Vázquez 3 4, José Luis Lanciego 1 2 3


It is without doubt that the gene therapy field is currently in the spotlight for the development of new therapeutics targeting unmet medical needs. Thus, considering the gene therapy scenario, neurological diseases in general and neurodegenerative disorders in particular are emerging as the most appealing choices for new therapeutic arrivals intended to slow down, stop, or even revert the natural progressive course that characterizes most of these devastating neurodegenerative processes.

Since an extensive coverage of all available literature is not feasible in practical terms, here emphasis was made in providing some advice to beginners in the field with a narrow focus on elucidating the best delivery route available for fulfilling any given AAV-based therapeutic approach.

Furthermore, it is worth nothing that the number of ongoing clinical trials is increasing at a breath-taking speed. Accordingly, a landscape view of preclinical and clinical initiatives is also provided here in an attempt to best illustrate what is ongoing in this quickly expanding field.

CITA DEL ARTICULO  Biomedicines. 2022 Mar 23;10(4):746. doi: 10.3390/biomedicines10040746.

Our authors

Dr. Ana Fajardo Serrano
Dr. Elvira Roda Recalde
Laboratory technician Neuroscience Research Program
Adriana Honrubia Castro
Laboratory technician Neuroscience Research Program
Dr. Sandra Arrieta Eguren
Goiaz Ariznabarreta Garabieta
Julia Chocarro García
Elena Lorenzo Ramos
Laboratory technician Neuroscience Research Program