"Radiopharmaceuticals allow us to observe the interior of the organism, in vivo, in a non-invasive way and thus obtain the molecular image of the organism or the disease to be studied".
DR. IVÁN PEÑUELAS SÁNCHEZ DIRECTOR. RADIOPHARMACY UNIT
The Micro-PET research platform is constituted as a research support unit with dependence and the Nuclear Medicine Service of the Clínica Universidad de Navarra and the Cima Universidad de Navarra.
PET (Positron Emission Tomography) is an in vivo molecular imaging technique that makes it possible to visualize and quantify a large number of biological and physiological processes. The technique is based on the use of different radiotracers labeled with positron emitters, whose biological affinity determines the information provided by the PET study.
The appearance in recent years of high-resolution tomographic equipment (Micro-PET) has made it possible to apply this technique to the study of small animals. One of the great advantages of this test is that since it is non-invasive, it allows longitudinal monitoring of the same animal throughout the experimental process.
The radiotracers necessary for cell marking are synthesized in the Clinic's Radiopharmacy Unit, the only Spanish hospital with the capacity to synthesize and apply 20 different radiopharmaceuticals.
- 18F-FDG Glycidal metabolism, tumor activity; cell labeling for early cell recruitment studies.
- 11C-Choline Phospholipid synthesis, tumor activity.
- 11C-Methionine Amino acid transport, tumor activity.
- 13N-ammonium Blood perfusion.
- 18F-FHBG Gene expression in vivo.
- 11C-DTBZ Vesicular monoamine transporter VMAT2 (dopaminergic innervation).
- 18F-DOPA Dopamine metabolism (dopaminergic innervation).
- 11C-Flumazenyl GABAergic receptors.
- 18F-Fluoride Bone metabolism.
- 11C-Acetate ß-oxidative metabolism.
Objectives of our platform
Research Support Unit
In vivo metabolic imaging techniques for the study of animal models, mainly by means of PET imaging and using radiopharmaceuticals produced by the Clinic's Radiopharmacy Unit.
Labeling of cells, peptides or nanoparticles with different radioisotopes for subsequent study by in vivo and/or ex vivo biodistribution techniques depending on the radioisotope used.
Ex vivo biodistribution studies after administration of radioactively labeled compounds by quantitative digital autoradiography and organ counting and dissection.
Equipment and services
- MicroPET equipment (Mosaic, Philips) dedicated to the study of small animals (mouse, rat, monkey).
- Quantitative digital autoradiography equipment (BAS 5000, Fujifilm).
- Whole body cryostat (Bright 8250).
- Isoflurane inhalation anesthesia equipment.
- Biological safety cabinet.
- Stabling area equipped with ventilated rack (HEPA filters) for animals under negative pressure.
Quantitative digital autoradiography services (biodistribution of compounds labeled with positron emitters, gamma emitters or β-emitters).
The benefit for our patients, having this wide variety of radiopharmaceuticals synthesized by the Radiopharmacy Unit, is to allow a more accurate diagnosis to determine the most appropriate treatment for complex pathologies such as prostate, brain and liver tumors, degenerative diseases such as Parkinson's or Alzheimer's and dementia in general.