Publicaciones científicas
- [INMUNOLOGÍA E INMUNOTERAPIA]
- [ESTRATEGIAS COMBINADAS DE INMUNOTERAPIA TRASLACIONAL]
- [DIVISIÓN DE CÁNCER]
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary
28-dic-2022
| Revista: Cancer Discovery
Ignacio Melero 1 2 3 4 , Miguel F Sanmamed 1 2 3 4 , Javier Glez-Vaz 1 2 , Carlos Luri-Rey 1 2 , Jun Wang 5 , Lieping Chen 6
Abstract
CD137 (4-1BB) is a costimulatory receptor of T and natural killer lymphocytes whose activity can be exploited in cancer immunotherapy strategies as discovered 25 years ago.
Following initial attempts that met unacceptable toxicity, new waves of constructs acting agonistically on CD137 are being developed in patients, offering signs of clinical and pharmacodynamic activity with tolerable safety profiles.
CITA DEL ARTÍCULO Cancer Discov. 2023 Mar 1;13(3):552-569. doi: 10.1158/2159-8290.CD-22-1029
Nuestros autores
Investigador Senior | Investigador principal
Programa de Investigación de Inmunología e Inmunoterapia
Investigador | Investigador principal
Grupo de Investigación en Onco-Inmunología Aplicada y Traslacional
Javier González Vaz
Carlos Luri