Scientific publications

CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary. Scientific Publication

Dec 28, 2022 | Magazine: Cancer Discovery

Ignacio Melero  1   2   3   4 , Miguel F Sanmamed  1   2   3   4 , Javier Glez-Vaz  1   2 , Carlos Luri-Rey  1   2 , Jun Wang  5 , Lieping Chen  6

Abstract

CD137 (4-1BB) is a costimulatory receptor of T and natural killer lymphocytes whose activity can be exploited in cancer immunotherapy strategies as discovered 25 years ago.

Following initial attempts that met unacceptable toxicity, new waves of constructs acting agonistically on CD137 are being developed in patients, offering signs of clinical and pharmacodynamic activity with tolerable safety profiles.

CITATION Cancer Discov. 2023 Mar 1;13(3):552-569. doi: 10.1158/2159-8290.CD-22-1029

see publication in pubmed

Our authors

Imagen del Dr. Ignacio Melero Bermejo, especialista en Inmunología de la Clínica Universidad de Navarra.
Dr. Ignacio Melero Bermejo Curriculum
Senior Researcher | Principal Investigator Immunology and Immunotherapy Research Program
Imagen del Dr. Miguel Fernández de Sanmamed Gutiérrez, Investigador principal del grupo Onco-Inmunología Aplicada y Traslacional de la Clínica Universidad de Navarra
Dr. Miguel Fernández de Sanmamed Gutiérrez Curriculum
Researcher | Principal Investigator Applied and Translational Onco-Immunology Research Group
Javier González Vaz
Predoctoral Immunology and Immunotherapy Research Program
Carlos Luri
Predoctoral Combination Strategies for Translational Immunotherapy Research Group