lncRNA-DNA hybrids regulate distant genes
Aina Maria Mas, Maite Huarte
lncRNAs actively regulate gene expression. They contribute to chromosomal interactions at close or distant genomic regions, which, in turn, regulate transcription . Ariel et al  reveal in a recent study a new molecular mechanism of the Arabidopsis lncRNA APOLO.
The authors extend previously reported functions of APOLO in cis-regulation of chromosomal looping and transcription of its neighbor gene to a set of distant genes involved in auxin-induced molecular pathways controlling lateral root development. Noteworthy, APOLO recognition of multiple trans-modulated targets occurs through a novel mechanism involving R-loop formation.
CITA DEL ARTÍCULO EMBO Rep. 2020 Mar 4;21(3):e50107. doi: 10.15252/embr.202050107. Epub 2020 Feb 20.