Scientific publications
A "Counter-Enhancer" in Tumor Suppression. Scientific Publication
May 31, 2018
| Magazine: Cell Press
Francesco P Marchese, Maite Huarte
Abstract
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.
CITATION Cell. 2018 May 31;173(6):1318-1319. doi: 10.1016/j.cell.2018.05.023.
Our authors
Dr.
Francesco Paolo Marchese
Director
Genomics Unit Platform
Researcher | Principal Investigator
Non-Coding RNA and Cancer Genome Group