Publicaciones científicas
- [TERAPIA GÉNICA Y REGULACIÓN DE LA EXPRESIÓN GÉNICA]
- [ARN NO CODIFICANTE Y REGULACIÓN DEL GENOMA DEL CÁNCER]
A "Counter-Enhancer" in Tumor Suppression
Francesco P Marchese, Maite Huarte
Abstract
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.
CITA DEL ARTÍCULO Cell. 2018 May 31;173(6):1318-1319. doi: 10.1016/j.cell.2018.05.023.

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