Publicaciones científicas
A "Counter-Enhancer" in Tumor Suppression
31-may-2018
| Revista: Cell Press
Francesco P Marchese, Maite Huarte
Abstract
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.
CITA DEL ARTÍCULO Cell. 2018 May 31;173(6):1318-1319. doi: 10.1016/j.cell.2018.05.023.
Nuestros autores
Dr.
Francesco Paolo Marchese
Director
Plataforma de Genómica
Investigadora | Investigadora principal
Grupo de Investigación de Regulación de la Expresión Génica