LKB1: Controlling Quiescence and Genomic Integrity at Home

Oct 1, 2018 | Magazine: Trends in Endocrinology & Metabolism

Carmen Berasain, Matías A Ávila

Abstract

The pleiotropic liver kinase B1 (LKB1) controls metabolism, cell polarity, and proliferation in an apparently cell- and context-specific manner. A recent study in Cell Reports has demonstrated that LKB1 is essential to maintain the characteristic quiescence of the liver and to secure genomic integrity during liver regeneration independently of AMPK

CITATION Trends Endocrinol Metab. 2018 Oct;29(10):668-670. doi: 10.1016/j.tem.2018.03.017. Epub 2018 Apr 5.

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Our authors

Dr. Carmen Berasain Lasarte Curriculum

Researcher | Principal Investigator Hepatology: Liquid Biopsy and Carcinogenesis Research Group

Dr. Matías Ávila Zaragozá Curriculum

Researcher | Principal Investigator Hepatology: Metabolism, Epigenetics and Carcinogenesis Research Group