Scientific publications

Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance

Jun 2, 2014 | Magazine: The Journal of Experimental Medicine

Juan Dubrot 1, Fernanda V Duraes 1, Lambert Potin 2, Francesca Capotosti 2, Dale Brighouse 1, Tobias Suter 3, Salomé LeibundGut-Landmann 4, Natalio Garbi 5, Walter Reith 1, Melody A Swartz 6, Stéphanie Hugues 7


Dendritic cells (DCs) and, more recently, lymph node stromal cells (LNSCs) have been described to tolerate self-reactive CD8(+) T cells in LNs.

Although LNSCs express MHCII, whether they can also impact CD4(+) T cell functions is unknown. We show that the promoter IV (pIV) of class II transactivator (CIITA), the master regulator of MHCII expression, controls endogenous MHCII expression by LNSCs.

Unexpectedly, LNSCs also acquire peptide-MHCII complexes from DCs and induce CD4(+) T cell dysfunction by presenting transferred complexes to naive CD4(+) T cells, preventing their proliferation and survival.

Our data reveals a novel, alternative mechanism where LN-resident stromal cells tolerate CD4(+) T cells by presenting self-antigens via transferred peptide-MHCII complexes of DC origin.

CITA DEL ARTÍCULO  J Exp Med. 2014 Jun 2;211(6):1153-66. doi: 10.1084/jem.20132000. Epub 2014 May 19.