Scientific publications
PD-L1 Crosslinking as a New Strategy of 4-1BB Agonism Immunotherapy
Aug 15, 2022
| Magazine: Clinical Cancer Research
Fei Shu 1, Salman R Punekar 2, Vamsidhar Velcheti 2, Miguel F Sanmamed 3, Jun Wang 1 2
Abstract
4-1BB has been considered a promising target in cancer immunotherapy for decades. Nevertheless, early 4-1BB-targeted agents demonstrated significant liver immuno-toxicity. A new wave of 4-1BB-based therapy is being developed to circumvent hepatotoxicity with a bispecific molecule that directs 4-1BB agonism to the tumor microenvironment by targeting tumor-associated immune checkpoint molecule PD-L1. See related article by Peper-Gabriel et al., p. 3387.
CITA DEL ARTÍCULO Clin Cancer Res. 2022 Aug 2;28(15):3182-3184. doi: 10.1158/1078-0432.CCR-22-0541.
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Researcher | Principal Investigator
Applied and Translational Onco-Immunology Research Group