Immunology and Immunotherapy

"Our team has developed very promising immunoregulatory molecules and vaccination strategies that are being evaluated in clinical trials."


Modulation of the immune system is revolutionizing the fight against cancer and infectious diseases. Recent advances show that an individual's immune system can be activated to eliminate tumor cells and extend patients' lives.

The Immunology and Immunotherapy Program at Cima focuses on the translational development of new therapeutic tools for the treatment of different types of cancers and infectious diseases. 

We have facilities for the production of therapeutic grade cells and the development and production of gene therapy vectors that allow us to optimize strategies that are in the clinical development phase, and to generate new immunotherapy alternatives for patients.

We have long experience in the development of novel vaccines that have led to patents and the creation of biotechnology companies.

Our innovative work in the development of immunomodulation strategies with the generation of very promising immunomodulatory molecules has also been the subject of patents and collaboration contracts with pharmaceutical companies.

We collaborate with pharmaceutical companies in the design and development of immunotherapy clinical trials in cancer patients. 

Our team is formed by nationally and internationally recognized researchers and immunologists from the Clínica Universidad de Navarra.

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Objectives of the Research Program in Immunology and Immunotherapy

Development of molecules and immunomodulation strategies

Identify and generate molecules with immunotherapeutic potential and develop immunomodulation strategies.

Therapeutic vaccines

Development of therapeutic vaccines against different types of cancer, infectious diseases and other pathologies.

Adoptive cell therapy

Design and evaluate adoptive cell therapy strategies for the treatment of oncologic diseases.

First Spanish immunotherapy

Cima and the Clínica Universidad de Navarra have coordinated a study that has managed to stabilize and improve the evolution in a group of patients with melanoma, lung cancer and renal cancer by combining the BO-112 molecule and two anti PD-1 antibodies (nivolumab or pembrolizumab). 

The BO-112 formulation is based on double-stranded RNA molecules and achieves a direct antitumor response that is in turn enhanced by activation of innate immunity mechanisms. This immunotherapy treatment is injected directly into the tumor or its metastases.

Our research groups

We seek to improve therapeutic alternatives against cancer by activating and boosting the immune system

Immunomodulation and
Tumor Microenvironment

Identification of small molecules that block Treg cell activity to develop antitumor therapies.

Combination Strategies for
Translational Immunotherapy

Study of immunomodulatory molecular mechanisms and their exploitation in cancer immunotherapy.


Identification of new targets to enhance the immune response against cancer.


Adoptive Cell Therapy

Strategies to improve the efficacy of adoptive cell transfer of tumor-infiltrating T lymphocytes (TILs).

Vaccine Development

Vaccination based on dendritic cell modulation.



Cutting-edge translational research

Our program is transversal and supports other Cima programs to promote, together with the clinical departments of the Clínica Universidad de Navarra, the development of specific reagents for immunomonitoring and the design of immunotherapies for different diseases, which can be applied in clinical activity.


We develop vaccines based on dendritic cells increasing their immunotherapeutic effect.

Relationships with companies

Our research has resulted in patents and several collaborations with national and international pharmaceutical companies.

Participation in clinical trials

We collaborate with industry in the development of clinical trials and promote our own clinical trials in collaboration with the Cell Therapy Area of the Clínica Universidad de Navarra.

<p>Fachada del Centro de Investigaci&oacute;n M&eacute;dica Aplicada (CIMA)</p>

Would you like to help us?

Thanks to the generosity of many people, the Cima Universidad de Navarra is a reality that strives to offer therapeutic solutions to achieve personalized medicine for patients.

Meet the research team

Scientific activity of the
Research Program in Immunology and Immunotherapy