Today's Special on the Anticancer Menu: Immunomodulation by Antifolates
Aitziber Buque, Lorenzo Galluzzi, Noelia Casares
Pemetrexed is widely employed for the clinical management of mesothelioma and non-small cell lung carcinoma, largely based on its ability to curtail folate metabolism in highly proliferating cells. Recent preclinical findings suggest that the therapeutic efficacy of pemetrexed may involve an unsuspected immunologic component.
CITATION Clin Cancer Res. 2019 Dec 1;25(23):6890-6892. doi: 10.1158/1078-0432.CCR-19-2775. Epub 2019 Sep 27.