Scientific publications

Today's Special on the Anticancer Menu: Immunomodulation by Antifolates

Dec 1, 2019 | Magazine: Clinical Cancer Research

Aitziber Buque, Lorenzo Galluzzi, Noelia Casares


Pemetrexed is widely employed for the clinical management of mesothelioma and non-small cell lung carcinoma, largely based on its ability to curtail folate metabolism in highly proliferating cells. Recent preclinical findings suggest that the therapeutic efficacy of pemetrexed may involve an unsuspected immunologic component.

CITATION  Clin Cancer Res. 2019 Dec 1;25(23):6890-6892. doi: 10.1158/1078-0432.CCR-19-2775. Epub 2019 Sep 27.