Interleukin-12 Message in a Bottle

Abstract

IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.

CITA DEL ARTÍCULO  Clin Cancer Res. 2020 Dec 1;26(23):6080-6082.