- [IMMUNOLOGY AND IMMUNOTHERAPY]
- [COMBINATION STRATEGIES FOR TRANSLATIONAL IMMUNOTHERAPY]
- [CYTOKINE-BASED THERAPEUTICS]
Interleukin-12 Message in a Bottle
Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero
IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.
CITA DEL ARTÍCULO Clin Cancer Res. 2020 Dec 1;26(23):6080-6082.