Scientific publications

Interleukin-12 Message in a Bottle. Scientific Publication

Dec 1, 2020 | Magazine: Clinical Cancer Research

Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero

Abstract

IL12 is a very potent cancer immunotherapy agent, but is difficult to harness safely if given systemically. Local gene transfer aims to confine the effects of IL12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticle mRNA achieves IL12 expression and efficacy in mouse models, opening the way to an ongoing trial.

CITATION Clin Cancer Res. 2020 Dec 1;26(23):6080-6082.

see publication in pubmed

Our authors

Dr. Pedro Berraondo López [SP] Curriculum

Researcher | Principal Investigator Cytokine-Based Therapeutics Research Group

Claudia Di Trani

Predoctoral Immunology and Immunotherapy Research Program

Imagen del Dr. Ignacio Melero Bermejo, especialista en Inmunología de la Clínica Universidad de Navarra.

Dr. Ignacio Melero Bermejo Curriculum

Senior Researcher | Principal Investigator Immunology and Immunotherapy Research Program