Modelos Animales
La plataforma de investigación en Modelos Animales dispone de modelos animales experimentales que cubren todo el espectro de necesidades de abordaje de las patologías que se investigan en el Cima Universidad de Navarra.
Cuenta con modelos in vitro, modelos in silico de modelización química y modelos animales in vivo.
En concreto, disponemos de modelos específicos para el estudio de enfermedades hepáticas, neurodegenerativas, cardíacas y varios tipos de cáncer. Estos modelos reflejan los procesos de desarrollo de la enfermedad en los pacientes y nos permiten realizar una investigación preclínica más precisa que busca dar respuestas a la necesidades médicas actuales.
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Conozca nuestros modelos animales
Lesión/insuficiencia hepática aguda y regeneración hepática
- Paracetamol, ethanol, Fas activation, hepatotoxins (CCI4 and I-naphthyl isothiocyanate).
- LPS/Galactosamine
- Partial hepatectomy
- PCLS
Daño hepático crónico
- Chronic CCI4 administration
- High fat diet (60% energy by fat) feeding
- Bile duct ligation
- Mdr2 knockout mice
Hepatocarcinogénesis
- HCC induction by chemical carcinogen (DEN)
- Xenograft models of HCC (subcutaneous and orthopic)
- Mdr2 knockout mice
Últimas publicaciones científicas
- Identification and experimental validation of druggable epigenetic targets in hepatoblastoma 24-oct-2023 | Revista: Journal of Hepatology
- Immunogenomic classification of hepatocellular carcinoma patients for immune check-point inhibitors therapy: cui bono? 09-ene-2023 | Revista: Gut
- FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma 04-ene-2023 | Revista: Molecular Therapy
- Understanding Carbohydrate Metabolism and Insulin Resistance in Acute Intermittent Porphyria 15-dic-2022 | Revista: International Journal of Molecular Sciences
Enfermedad de Alzheimer
- APP/PS1
- Tg2576
Enfermedad de Parkinson
- MPTP
- Haloperidol
- 6-OHDA
Esquizofrenia
- Ketamine
- PCP
- mk-801
Últimas publicaciones científicas
- Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models 19-jul-2023 | Revista: Neurobiology of Disease
- Microglia and astrocyte activation is region-dependent in theα-synuclein mouse model of Parkinson's disease 15-mar-2023 | Revista: Glia
- Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis 01-oct-2022 | Revista: Neurology-Oncology
- Adeno-Associated Viral Vectors as Versatile Tools for Neurological Disorders: Focus on Delivery Routes and Therapeutic Perspectives 23-mar-2022 | Revista: Biomedicines
Trombosis
- Ferric chloride induced carotid thrombosis
- Rose Bengal/laser induced carotid thrombosis
- Lung thromboembolism model
- Tail bleeding (hemorrhagic complications)
Accidente cerebrovascular
Thromboembolic model of stroke in mice:
- Thrombolytic treatment
- Comorbidities: atherosclerosis, diabetes type 1
Últimas publicaciones científicas
- Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology 24-oct-2023 | Revista: European Journal of Heart Failure
- Prediction of Left Ventricular Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides 11-ene-2023 | Revista: Journal of the American College of Cardiology: Heart Failure
- ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased transforming growth factor beta signalling after pressure overload 20-dic-2022 | Revista: Communications Biology
- Impact analysis of heart failure across European countries: an ESC-HFA position paper 09-oct-2022 | Revista: ESC Heart Failure
Adenocarcinoma
- Genetically modified (Kras mutation)
- Chemichal carcinogen induced and synergic models (urethane+silice and DNMA)
Carcinoma de células escamosas
- Chemical carcinogen induced and syngeneic models (NCTU)
Modelos de injertos tumorales de cáncer de pulmón
(subcutáneos y ortotópicos)
- Human cell lines
- Adenocarcinoma cell lines
- Squamous Cell Carcinoma cell lines
Últimas publicaciones científicas
- FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis 27-ene-2025 | Revista: Journal of Translational Medicine
- DSTYK Inhibition Sensitizes Non-Small Cell Lung Cancer To Taxane-Based Chemotherapy 11-nov-2024 | Revista: Journal of Thoracic Oncology
- Safe and successful gut-restricted adsorbent strategy against cirrhosis and acute-on-chronic liver failure 26-oct-2024 | Revista: Gut
- Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates 04-oct-2024 | Revista: Gut