Modelos Animales
La plataforma de investigación en Modelos Animales dispone de modelos animales experimentales que cubren todo el espectro de necesidades de abordaje de las patologías que se investigan en el Cima Universidad de Navarra.
Cuenta con modelos in vitro, modelos in silico de modelización química y modelos animales in vivo.
En concreto, disponemos de modelos específicos para el estudio de enfermedades hepáticas, neurodegenerativas, cardíacas y varios tipos de cáncer. Estos modelos reflejan los procesos de desarrollo de la enfermedad en los pacientes y nos permiten realizar una investigación preclínica más precisa que busca dar respuestas a la necesidades médicas actuales.
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Conozca nuestros modelos animales
Lesión/insuficiencia hepática aguda y regeneración hepática
- Paracetamol, ethanol, Fas activation, hepatotoxins (CCI4 and I-naphthyl isothiocyanate).
- LPS/Galactosamine
- Partial hepatectomy
- PCLS
Daño hepático crónico
- Chronic CCI4 administration
- High fat diet (60% energy by fat) feeding
- Bile duct ligation
- Mdr2 knockout mice
Hepatocarcinogénesis
- HCC induction by chemical carcinogen (DEN)
- Xenograft models of HCC (subcutaneous and orthopic)
- Mdr2 knockout mice
Últimas publicaciones científicas
- FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma 04-ene-2023 | Revista: Molecular Therapy
- New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming 26-may-2022 | Revista: Journal of Experimental & Clinical Cancer Research
- JIND: Joint Integration and Discrimination for Automated Single-Cell Annotation 07-mar-2022 | Revista: Bioinformatics
- Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria 12-ene-2022 | Revista: Science Translational Medicine
Enfermedad de Alzheimer
- APP/PS1
- Tg2576
Enfermedad de Parkinson
- MPTP
- Haloperidol
- 6-OHDA
Esquizofrenia
- Ketamine
- PCP
- mk-801
Últimas publicaciones científicas
- Microglia and astrocyte activation is region-dependent in theα-synuclein mouse model of Parkinson's disease 10-nov-2022 | Revista: Glia
- Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis 01-oct-2022 | Revista: Neurology-Oncology
- Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism 04-mar-2022 | Revista: Brain
- An interactive framework for the detection of ictal and interictal activities 02-mar-2022 | Revista: Computer Methods and Programs in Biomedicine
Trombosis
- Ferric chloride induced carotid thrombosis
- Rose Bengal/laser induced carotid thrombosis
- Lung thromboembolism model
- Tail bleeding (hemorrhagic complications)
Accidente cerebrovascular
Thromboembolic model of stroke in mice:
- Thrombolytic treatment
- Comorbidities: atherosclerosis, diabetes type 1
Últimas publicaciones científicas
- Prediction of Left Ventricular Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides 11-ene-2023 | Revista: Journal of the American College of Cardiology: Heart Failure
- Impact analysis of heart failure across European countries: an ESC-HFA position paper 09-oct-2022 | Revista: ESC Heart Failure
- Failing Hypertensive Heart: a Question of Altered Telomere Biology? 01-oct-2022 | Revista: Hypertension
- The association between markers of type I collagen synthesis and echocardiographic response to spironolactone in patients at risk of heart failure: findings from the HOMAGE trial 24-sep-2022 | Revista: European Journal of Heart Failure
Adenocarcinoma
- Genetically modified (Kras mutation)
- Chemichal carcinogen induced and synergic models (urethane+silice and DNMA)
Carcinoma de células escamosas
- Chemical carcinogen induced and syngeneic models (NCTU)
Modelos de injertos tumorales de cáncer de pulmón
(subcutáneos y ortotópicos)
- Human cell lines
- Adenocarcinoma cell lines
- Squamous Cell Carcinoma cell lines
Últimas publicaciones científicas
- The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer 01-may-2023 | Revista: Molecular Cancer
- Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma 16-mar-2023 | Revista: Nature Medicine
- Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors 01-feb-2023 | Revista: STAR Protocols
- Lamc2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth 06-ene-2023 | Revista: Clinical Cancer Research