Animal Models
The Animal Models research platform has experimental animal models that cover the entire spectrum of needs for the pathologies investigated at the Cima Universidad de Navarra.
It has in vitro models, in silico models of chemical modeling and in vivo animal models.
Specifically, we have specific models for the study of liver, neurodegenerative, cardiac diseases and several types of cancer. These models reflect the processes of disease development in patients and allow us to carry out more precise preclinical research that seeks to provide answers to current medical needs.
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Learn about our animal models
Acute liver injury/failure and liver regeneration
- Paracetamol, ethanol, Fas activation, hepatotoxins (CCI4 and I-naphthyl isothiocyanate).
- LPS/Galactosamine
- Partial hepatectomy
- PCLS
Chronic liver damage
- Chronic CCI4 administration
- High fat diet (60% energy by fat) feeding
- Bile duct ligation
- Mdr2 knockout mice
Hepatocarcinogenesis
- HCC induction by chemical carcinogen (DEN)
- Xenograft models of HCC (subcutaneous and orthopic)
- Mdr2 knockout mice
Latest scientific publications
- Identification and experimental validation of druggable epigenetic targets in hepatoblastoma Oct 24, 2023 | Magazine: Journal of Hepatology
- Immunogenomic classification of hepatocellular carcinoma patients for immune check-point inhibitors therapy: cui bono? Jan 9, 2023 | Magazine: Gut
- FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma Jan 4, 2023 | Magazine: Molecular Therapy
- Understanding Carbohydrate Metabolism and Insulin Resistance in Acute Intermittent Porphyria Dec 15, 2022 | Magazine: International Journal of Molecular Sciences
Alzheimer's disease
- APP/PS1
- Tg2576
Parkinson's disease
- MPTP
- Haloperidol
- 6-OHDA
Schizophrenia
- Ketamine
- PCP
- mk-801
Latest scientific publications
- Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models Jul 19, 2023 | Magazine: Neurobiology of Disease
- Microglia and astrocyte activation is region-dependent in theα-synuclein mouse model of Parkinson's disease Mar 15, 2023 | Magazine: Glia
- Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis Oct 1, 2022 | Magazine: Neurology-Oncology
- Adeno-Associated Viral Vectors as Versatile Tools for Neurological Disorders: Focus on Delivery Routes and Therapeutic Perspectives Mar 23, 2022 | Magazine: Biomedicines
Thrombosis
- Ferric chloride induced carotid thrombosis
- Rose Bengal/laser induced carotid thrombosis
- Lung thromboembolism model
- Tail bleeding (hemorrhagic complications)
Stroke
Thromboembolic model of stroke in mice:
- Thrombolytic treatment
- Comorbidities: atherosclerosis, diabetes type 1
Latest scientific publications
- Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology Oct 24, 2023 | Magazine: European Journal of Heart Failure
- Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature Jan 11, 2023 | Magazine: Journal of the American College of Cardiology: Heart Failure
- ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased transforming growth factor beta signalling after pressure overload Dec 20, 2022 | Magazine: Communications Biology
- Impact analysis of heart failure across European countries: an ESC-HFA position paper Oct 9, 2022 | Magazine: ESC Heart Failure
Adenocarcinoma
- Genetically modified (Kras mutation)
- Chemichal carcinogen induced and synergic models (urethane+silice and DNMA)
Squamous cell carcinoma
- Chemical carcinogen induced and syngeneic models (NCTU)
Lung cancer tumor graft models
(subcutaneous and orthotopic)
- Human cell lines
- Adenocarcinoma cell lines
- Squamous Cell Carcinoma cell lines
Latest scientific publications
- FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis Jan 27, 2025 | Magazine: Journal of Translational Medicine
- DSTYK Inhibition Sensitizes Non-Small Cell Lung Cancer To Taxane-Based Chemotherapy Nov 11, 2024 | Magazine: Journal of Thoracic Oncology
- Safe and successful gut-restricted adsorbent strategy against cirrhosis and acute-on-chronic liver failure Oct 26, 2024 | Magazine: Gut
- Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates Oct 4, 2024 | Magazine: Gut