PLATFORM

Animal Models

The Animal Models research platform has experimental animal models that cover the entire spectrum of needs for the pathologies investigated at the Cima Universidad de Navarra.

It has in vitro models, in silico models of chemical modeling and in vivo animal models.  

Specifically, we have specific models for the study of liver, neurodegenerative, cardiac diseases and several types of cancer. These models reflect the processes of disease development in patients and allow us to carry out more precise preclinical research that seeks to provide answers to current medical needs. 

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Learn about our animal models

Acute liver injury/failure and liver regeneration
  • Paracetamol, ethanol, Fas activation, hepatotoxins (CCI4 and I-naphthyl isothiocyanate).
  • LPS/Galactosamine
  • Partial hepatectomy
  • PCLS
Chronic liver damage
  • Chronic CCI4 administration
  • High fat diet (60% energy by fat) feeding
  • Bile duct ligation
  • Mdr2 knockout mice
Hepatocarcinogenesis
  • HCC induction by chemical carcinogen (DEN)
  • Xenograft models of HCC (subcutaneous and orthopic)
  • Mdr2 knockout mice
Thrombosis
  • Ferric chloride induced carotid thrombosis
  • Rose Bengal/laser induced carotid thrombosis
  • Lung thromboembolism model
  • Tail bleeding (hemorrhagic complications)
Stroke

Thromboembolic model of stroke in mice:

  • Thrombolytic treatment
  • Comorbidities: atherosclerosis, diabetes type 1

Latest scientific publications

Adenocarcinoma
  • Genetically modified (Kras mutation)
  • Chemichal carcinogen induced and synergic models (urethane+silice and DNMA)
Squamous cell carcinoma
  • Chemical carcinogen induced and syngeneic models (NCTU)
Lung cancer tumor graft models
(subcutaneous and orthotopic)
  • Human cell lines
  • Adenocarcinoma cell lines
  • Squamous Cell Carcinoma cell lines