Animal Models
The Animal Models research platform has experimental animal models that cover the entire spectrum of needs for the pathologies investigated at the Cima Universidad de Navarra.
It has in vitro models, in silico models of chemical modeling and in vivo animal models.
Specifically, we have specific models for the study of liver, neurodegenerative, cardiac diseases and several types of cancer. These models reflect the processes of disease development in patients and allow us to carry out more precise preclinical research that seeks to provide answers to current medical needs.
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Learn about our animal models
Acute liver injury/failure and liver regeneration
- Paracetamol, ethanol, Fas activation, hepatotoxins (CCI4 and I-naphthyl isothiocyanate).
- LPS/Galactosamine
- Partial hepatectomy
- PCLS
Chronic liver damage
- Chronic CCI4 administration
- High fat diet (60% energy by fat) feeding
- Bile duct ligation
- Mdr2 knockout mice
Hepatocarcinogenesis
- HCC induction by chemical carcinogen (DEN)
- Xenograft models of HCC (subcutaneous and orthopic)
- Mdr2 knockout mice
Latest scientific publications
- New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming May 26, 2022 | Magazine: Journal of Experimental & Clinical Cancer Research
- JIND: Joint Integration and Discrimination for Automated Single-Cell Annotation Mar 7, 2022 | Magazine: Bioinformatics
- Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB 1 and CB 2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia Jan 12, 2022 | Magazine: Science Translational Medicine
- The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis Dec 28, 2021 | Magazine: The American Journal of Gastroenterology
Alzheimer's disease
- APP/PS1
- Tg2576
Parkinson's disease
- MPTP
- Haloperidol
- 6-OHDA
Schizophrenia
- Ketamine
- PCP
- mk-801
Latest scientific publications
- Microglia and astrocyte activation is region-dependent in theα-synuclein mouse model of Parkinson's disease Nov 10, 2022 | Magazine: Glia
- Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis Oct 1, 2022 | Magazine: Neurology-Oncology
- Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism Mar 4, 2022 | Magazine: Brain
- An interactive framework for the detection of ictal and interictal activities Mar 2, 2022 | Magazine: Computer Methods and Programs in Biomedicine
Thrombosis
- Ferric chloride induced carotid thrombosis
- Rose Bengal/laser induced carotid thrombosis
- Lung thromboembolism model
- Tail bleeding (hemorrhagic complications)
Stroke
Thromboembolic model of stroke in mice:
- Thrombolytic treatment
- Comorbidities: atherosclerosis, diabetes type 1
Latest scientific publications
- Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature Jan 11, 2023 | Magazine: Journal of the American College of Cardiology: Heart Failure
- A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy Jun 14, 2022 | Magazine: Cancers
- Lipocalin-2 and Calprotectin Potential Prognosis Biomarkers in Peripheral Arterial Disease Mar 16, 2022 | Magazine: European Journal of Vascular and Endovascular Surgery
- Biomarker-based assessment of collagen cross-linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling Nov 28, 2021 | Magazine: European Journal of Heart Failure
Adenocarcinoma
- Genetically modified (Kras mutation)
- Chemichal carcinogen induced and synergic models (urethane+silice and DNMA)
Squamous cell carcinoma
- Chemical carcinogen induced and syngeneic models (NCTU)
Lung cancer tumor graft models
(subcutaneous and orthotopic)
- Human cell lines
- Adenocarcinoma cell lines
- Squamous Cell Carcinoma cell lines
Latest scientific publications
- Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma Mar 16, 2023 | Magazine: Nature Medicine
- Lamc2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth Jan 6, 2023 | Magazine: Clinical Cancer Research
- DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity Sep 28, 2022 | Magazine: The Journal of Experimental Medicine
- Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma Jun 30, 2022 | Magazine: New England of Medicine