Animal Models
The Animal Models research platform has experimental animal models that cover the entire spectrum of needs for the pathologies investigated at the Cima Universidad de Navarra.
It has in vitro models, in silico models of chemical modeling and in vivo animal models.
Specifically, we have specific models for the study of liver, neurodegenerative, cardiac diseases and several types of cancer. These models reflect the processes of disease development in patients and allow us to carry out more precise preclinical research that seeks to provide answers to current medical needs.
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Learn about our animal models
Acute liver injury/failure and liver regeneration
- Paracetamol, ethanol, Fas activation, hepatotoxins (CCI4 and I-naphthyl isothiocyanate).
- LPS/Galactosamine
- Partial hepatectomy
- PCLS
Chronic liver damage
- Chronic CCI4 administration
- High fat diet (60% energy by fat) feeding
- Bile duct ligation
- Mdr2 knockout mice
Hepatocarcinogenesis
- HCC induction by chemical carcinogen (DEN)
- Xenograft models of HCC (subcutaneous and orthopic)
- Mdr2 knockout mice
Latest scientific publications
- Identification and experimental validation of druggable epigenetic targets in hepatoblastoma Oct 24, 2023 | Magazine: Journal of Hepatology
- Immunogenomic classification of hepatocellular carcinoma patients for immune check-point inhibitors therapy: cui bono? Jan 9, 2023 | Magazine: Gut
- FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma Jan 4, 2023 | Magazine: Molecular Therapy
- Understanding Carbohydrate Metabolism and Insulin Resistance in Acute Intermittent Porphyria. Dec 15, 2022 | Magazine: International Journal of Molecular Sciences
Alzheimer's disease
- APP/PS1
- Tg2576
Parkinson's disease
- MPTP
- Haloperidol
- 6-OHDA
Schizophrenia
- Ketamine
- PCP
- mk-801
Latest scientific publications
- Microglia and astrocyte activation is region-dependent in theα-synuclein mouse model of Parkinson's disease Nov 10, 2022 | Magazine: Glia
- Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis Oct 1, 2022 | Magazine: Neurology-Oncology
- Adeno-Associated Viral Vectors as Versatile Tools for Neurological Disorders: Focus on Delivery Routes and Therapeutic Perspectives Mar 23, 2022 | Magazine: Biomedicines
- Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism Mar 4, 2022 | Magazine: Brain
Thrombosis
- Ferric chloride induced carotid thrombosis
- Rose Bengal/laser induced carotid thrombosis
- Lung thromboembolism model
- Tail bleeding (hemorrhagic complications)
Stroke
Thromboembolic model of stroke in mice:
- Thrombolytic treatment
- Comorbidities: atherosclerosis, diabetes type 1
Latest scientific publications
- Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature Jan 11, 2023 | Magazine: Journal of the American College of Cardiology: Heart Failure
- ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased transforming growth factor beta signalling after pressure overload Dec 20, 2022 | Magazine: Communications Biology
- Impact analysis of heart failure across European countries: an ESC-HFA position paper Oct 9, 2022 | Magazine: ESC Heart Failure
- Failing Hypertensive Heart: a Question of Altered Telomere Biology? Oct 1, 2022 | Magazine: Hypertension
Adenocarcinoma
- Genetically modified (Kras mutation)
- Chemichal carcinogen induced and synergic models (urethane+silice and DNMA)
Squamous cell carcinoma
- Chemical carcinogen induced and syngeneic models (NCTU)
Lung cancer tumor graft models
(subcutaneous and orthotopic)
- Human cell lines
- Adenocarcinoma cell lines
- Squamous Cell Carcinoma cell lines
Latest scientific publications
- The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer May 1, 2023 | Magazine: Molecular Cancer
- Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson's disease Apr 5, 2023 | Magazine: JPJ Parkinson's Disease
- Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma Mar 16, 2023 | Magazine: Nature Medicine
- Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors Feb 1, 2023 | Magazine: STAR Protocols