Brain tumors research

Glioblastoma

Brain tumors originate from cells of the central nervous system, consisting of the brain (cerebrum, cerebellum and brainstem) and the spinal cord.

Central nervous system tumors are very aggressive tumors that grow and spread rapidly, limiting treatment options. Together with bone tumors, they are the leading cause of cancer mortality in children.

In adults, glioblastoma, also known as glioblastoma multiforme, is the most aggressive brain tumor. This tumor arises in the brain or spinal cord. Glioblastomas form from cells called astrocytes, which provide support for neurons.

Glioblastoma can cause headaches, nausea, vomiting and seizures. It is a very difficult type of tumor to treat. Treatments based on surgery, radio and/or polychemotherapy can slow the progression of the cancer and reduce signs and symptoms. However, overall survival has not improved substantially in recent years.

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We dream of curing brain tumors

Treatment options have increased significantly in recent years, but much remains to be discovered.

To deepen the knowledge of the underlying biology of these tumors, the mechanisms involved in their development and the tumor microenvironment.

We seek to find new biomarkers of the disease and to develop new specific therapeutic strategies targeting these tumors.

We work closely with researchers and clinicians to rapidly translate findings from the laboratory to the patient.

REFERENCES IN TRANSLATIONAL RESEARCH

Pediatric Solid Tumor Research Group

Reference team in the research of childhood and adult brain tumors focused on the development of new therapeutic strategies based, preferably, on oncolytic viruses with which to modulate the immune system.

To evaluate these therapies we have relevant preclinical models, always with an eye on the patient.

It is part of the Solid Tumors Program.