Scientific publications
Senescent T Cells as a Resistance Mechanism to Lung Cancer Immunotherapy
Jan 15, 2021
| Magazine: Clinical Cancer Research
Diego Salas-Benito 1, Iñaki Eguren-Santamaria 1, Miguel F Sanmamed 2 3 4 5
Abstract
It has been reported that a group of patients with advanced non-small cell lung cancer showed circulating T cells with a senescent phenotype, and an abundance of such cells is associated with worse clinical response to immune checkpoint inhibitors. This study encourages further analysis of the role of senescent T cells in resistance to lung cancer immunotherapy.See related article by Ferrara et al., p. 492.
CITATION Clin Cancer Res. 2021 Jan 15;27(2):374-376. doi: 10.1158/1078-0432.CCR-20-3507. Epub 2020 Nov 13.
Our authors
Researcher | Principal Investigator
Applied and Translational Onco-Immunology Research Group