"One of the most novel applications is the use of aptamers to deliver in vivo a cargo (siRNA or even another aptamer) to a target cell."
DR. FERNANDO PASTOR RODRÍGUEZ RESEARCHER. APTAMER RESEARCH GROUP
The Aptamer Group of the Cima Universidad de Navarra focuses its research on the generation of aptamers with the capacity to induce and potentiate the anti-tumor immune response.
It has developed antagonist and agonist aptamers to modulate the function of a receptor, inhibiting or activating it according to therapeutic requirements. One of the most novel applications of this technology is the use of aptamers to deliver a cargo to a target cell in vivo; the nature of the cargo can range from an siRNA to another aptamer.
Aptamers are small single-stranded RNA or DNA molecules that acquire very complex secondary structures. They exhibit similar or higher affinities and specificities than monoclonal antibodies.
The use of aptamers extends to the therapeutic and diagnostic field; in addition, they can be used as an efficient delivery system for small molecules. Several aptamers are currently in clinical trials; one of them has recently been approved by the FDA for use in macular degeneration.
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Objectives of our research
Real alternative to monoclonal antibodies in biomedical, diagnostic and therapeutic research.
Development of therapeutic agents with high affinity and specificity for various diseases.
Clinical trials to validate the use of aptamers to enhance the immune response against tumors.
Design and synthesis of aptamers
They are selected using the SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technique, a complex technique consisting of multiple binding, partitioning and elution steps.
This whole process is carried out in the laboratories of the Cima Universidad de Navarra.
NEW THERAPEUTIC TARGETS
To discover new molecular therapies that may address unmet medical needs.
In-vitro and in-vivo validation
In order to know the efficacy and safety of new targets or mechanisms of action of clinical interest through the use of new molecules.
Development of therapeutic agents
Design of new molecules for multifactorial optmization to reach the patient as quickly as possible.
We make it possible for external companies, with capacity and resources, to invest in the project and take it to the patient, which is our main objective.
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Thanks to the generosity of many people, the Cima Universidad de Navarra is a reality that strives to offer therapeutic solutions to achieve personalized medicine for patients.
Meet the research team
Scientific activity of the
Aptamer Research Group
Latest scientific publications
- Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge? Sep 4, 2020 | Magazine: Molecular Therapy-Nucleic Acids
- ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity Nov 6, 2019 | Magazine: Molecular Therapy
- Intratumoral injection of activated B lymphoblast in combination with PD-1 blockade induces systemic antitumor immunity with reduction of local and distal tumors Apr 9, 2018 | Magazine: OncoImmunology
- Decoy-Based, Targeted Inhibition of STAT3: A New Step forward for B Cell Lymphoma Immunotherapy Mar 7, 2018 | Magazine: Molecular Therapy