Combination Strategies for Translational Immunotherapy
"We work on anti-cancer strategies such as the use of monoclonal antibodies, therapeutic tools that provide instructions to immune system cells to eradicate tumors."
DR. IGNACIO MELERO BERMEJO SENIOR RESEARCHER. COMBINATION STRATEGIES FOR TRANSLATIONAL IMMUNOTHERAPY RESEARCH GROUP
The Combination Strategies for Translational Immunotherapy Group at Cima focuses on identifying and developing new immunomodulatory therapeutic strategies and mechanisms of action of antitumor immunity to exploit them in combined immunotherapy strategies against cancer.
Our group is formed by researchers and clinicians who approach cancer immunotherapy from an interdisciplinary and highly translational perspective. We use novel models and experimental approaches both at the preclinical level and from a translational approach.
Our group participates in multiple early clinical trials of cancer immunotherapy that include first administrations to humans.
We rely on animal models, human samples from cancer patients, and a team with extensive experience in immune cell biology, immunology, and clinical oncology to answer our experimental questions from a comprehensive approach.
![Ignacio Melero](/dam/cima/imagenes/programas/ip-programas-grupos/IP_ppal_melero.png)
Dr. Ignacio Melero
GROUP LEADER
+34 948 194 700 | Ext. 81 4030 | |
imelero@unav.es | |
Research profile |
Objectives of the Research Group in
Combination Strategies for Translational Immunotherapy
![icono-naranja-celulas-plasma-sangre](/.imaging/default/dam/cima/imagenes/imagenes-iconos/icono-naranja-celulas-plasma-sangre/jcr:content.png)
Modulation of the immune response in the tumor microenvironment by local injection of different immunomodulatory agents and compounds.
![icono-naranja.neurona](/.imaging/default/dam/cima/imagenes/imagenes-iconos/icono-naranja/jcr:content.png)
Exploitation of cross-presentation (crosspriming) and specialized crosspriming dendritic cells for activation of anti-tumor immunity.
![icono-naranja-anticuerpo](/.imaging/default/dam/cima/imagenes/imagenes-iconos/icono-naranja-anticuerpo/jcr:content.png)
Study of the molecular mechanisms of co-stimulation and co-inhibition of effector immune cells.
![icono-naranja-tumor](/.imaging/default/dam/cima/imagenes/imagenes-iconos/icono-naranja-tumor/jcr:content.png)
Study of IL-8 as an immunomodulatory mechanism and potential biomarker in cancer.
![reunion-participantes-proyecto-linterna Arranca el proyecto Linterna, un consorcio creado para impulsar la inmunoterapia contra el cáncer en Navarra](/.imaging/mte/cima/half/dam/cima/imagenes/noticias/reunion-participantes-proyecto-linterna/jcr:content/reunion-participantes-proyecto-linterna.jpg)
FROM THE LABORATORY TO THE CLINIC
Regional commitment to translational research
Our group coordinates the Linterna Project, a multicenter project funded by the Government of Navarra, which proposes to strengthen the cutting-edge translational research being carried out in Navarra by research centers, hospital complexes, and pharmaceutical companies.
Lines of research
Objectives:
Development of new preclinical tools for immunotherapy research in melanoma and identification of potential biomarkers.
PI: Bruno Paiva y Patricia Maiso
Objectives:
- Analyze the mechanisms of action and synergy of efficacy in tumor cells and immune system.
- Implement new generation biomarkers to monitor clinical trials.
Meet the research team
![Ana Rouzaut. Programa Inmunología. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/ana-rouzaut-subira/jcr:content/ana-rouzaut-subira.jpg)
![Silueta investigadores. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/silueta-cima/jcr:content/silueta-cima.png)
![Laura Mosteo López. Estudiante postdoctoral del programa Inmunología e Inmunoterapia del Cima Universidad de Navarra.](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/investigadores/mosteo-laura/jcr:content/mosteo-laura.jpg)
![Arantza Azpilicueta. Programa Inmunología e Inmunoterapia. Cima](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/arantza-azpilicueta-lusarreta/jcr:content/arantza-azpilicueta-lusarreta.jpg)
![Elixabet Bolaños. Programa Inmunología e Inmunoterapia. Cima](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/elixabet-bolanos-mateo/jcr:content/elixabet-bolanos-mateo.jpg)
![Inmaculada Rodriguez. Inmunología e Inmunoterapia. Cima Técnico de laboratorio del Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/inmaculada-rodriguez-lopez/jcr:content/inmaculada-rodriguez-lopez.jpg)
![Sandra Sánchez. Programa Inmunología e Inmunoterapia. Cima](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/sandra-sanchez-gregorio/jcr:content/sandra-sanchez-gregorio.jpg)
![Iranzu Serrano. Programa Inmunología e Inmunoterapia. Cima](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/iranzu-serrano-mendioroz/jcr:content/iranzu-serrano-mendioroz.jpg)
![Nekane Soria Picón. Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/nekane-soria-picon/jcr:content/nekane-soria-picon.jpg)
![Saioa Arrieta. Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/saioa-arrieta-aranzueque/jcr:content/saioa-arrieta-aranzueque.jpg)
![Silueta investigadores. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/silueta-cima/jcr:content/silueta-cima.png)
![Raquel Cuesta. Técnico de laboratorio del programa Inmunología e Inmunoterapia del Cima Universidad de Navarra.](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/investigadores/cuesta-raquel/jcr:content/cuesta-raquel.jpg)
![Mario García Dominguez. Técnico de laboratorio del programa Inmunología e Inmunoterapia del Cima Universidad de Navarra.](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/investigadores/garcia-dominguez-mario/jcr:content/garcia-dominguez-mario.jpg)
![Dayanna Salinas Espinosa. Técnico de laboratorio del programa Inmunología e Inmunoterapia del Cima Universidad de Navarra.](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/investigadores/salinas-dayanna/jcr:content/salinas-dayanna.jpg)
![David Ruiz Guillamón. Bioinformático del programa Inmunología e Inmunoterapia del Cima Universidad de Navarra.](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/investigadores/ruiz-guillamon-david/jcr:content/ruiz-guillamon-david.jpg)
![Carlos Luri. Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/carlos-luri/jcr:content/carlos-luri.jpg)
![Eneko Garate. Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/eneko-garate/jcr:content/eneko-garate.jpg)
![Gabriel Gomis. Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/gabriel-gomis/jcr:content/gabriel-gomis.jpg)
![Paula Molero González. Estudiante predoctoral del programa Inmunología e Inmunoterapia del Cima Universidad de Navarra.](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/investigadores/molero-paula/jcr:content/molero-paula.jpg)
![Eva Olivero Cabezuelo. Project Manager. Programa de Inmunología e Inmunoterapia. Cima Universidad de Navarra Gestora de Proyectos del Programa de Inmunología e Inmunoterapia del Cima Universidad de Navarra](/.imaging/mte/cima/profesional_carrusel-80x80/dam/cima/imagenes/profesionales/programas-transversales/inmunologia-inmunoterapia/eva-olivero-cabezuelo/jcr:content/eva-olivero-cabezuelo.webp)
Scientific activity of the Combination Strategies for Translational Immunotherapy Research Group
Latest scientific publications
- CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects Aug 18, 2023 | Magazine: Science Advances
- Methods to assess radiation induced abscopal responses in mice Mar 28, 2023 | Magazine: Methods in Cell Biology
- CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary Dec 28, 2022 | Magazine: Cancer Discovery
- Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity Oct 6, 2022 | Magazine: Cells