Scientific publications

Druggable targets in cytokine release syndromes. Scientific Publication

Sep 1, 2023 | Magazine: Clinical Cancer Research

Carlos Luri-Rey  1 , Iñaki Eguren-Santamaria  2 , Ignacio Matos  3 , Pedro Berraondo  4 , Ignacio Melero  5

Abstract

Bispecific T-cell engagers and CAR T-cells share the problem of eliciting acute systemic inflammation episodes known as Cytokine Release Syndrome (CRS).

Knowledge on the sequential waves of cytokines that can be neutralized with clinically available agents is crucial to prevent or treat this condition without jeopardizing the antitumor therapeutic outcome.

CITATION  Clin Cancer Res. 2023 Sep 1. doi: 10.1158/1078-0432.CCR-23-1975

see publication in pubmed

Our authors

Carlos Luri Rey
Predoctoral Combination Strategies for Translational Immunotherapy Research Group
Dr. Iñaki Eguren Santamaría [SP] Curriculum
Predoctoral Applied and Translational Onco-Immunology Research Group
Dr. Pedro Berraondo López Curriculum
Researcher | Principal Investigator Cytokine-Based Therapeutics Research Group
Imagen del Dr. Ignacio Melero Bermejo, especialista en Inmunología de la Clínica Universidad de Navarra.
Dr. Ignacio Melero Bermejo Curriculum
Researcher | Principal Investigator Combination Strategies for Translational Immunotherapy Research Group