Bioinformatics
"Our focus is on technological innovation that is carried out within the framework of national and international projects."
DR. MIKEL HERNÁEZ DIRECTOR. BIOINFORMATICS PLATFORM
The Bioinformatics platform aims to contribute to the development of research projects carried out at Cima. To this end, it offers complete support in the development of any experiment in which DNA or RNA is studied on a massive scale, both in humans and in other organisms.
Bioinformatics allows, with data from proteomics experiments, the development of new applications, such as the identification of biomarkers or new therapeutic targets for drug development.
The computational needs faced by bioinformatics have arisen mainly due to the management of large amounts of information, image and spectrum processing and database searching.
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A platform at the service of patients and research
Experimental design
Advice on sample size, study design and methodology planning.
Data analysis
Bioinformatic processing of data obtained in various high-performance technological platforms.
Interpretation of results
Once the genes of interest have been selected, biological-functional assignment studies are performed.
Bioinformatics Services
- Differential expression of genes, miRNAs or lncRNAs. The technology of origin of the experiments can be microarrays (Affymetrix, Agilent), bulk PCRs (TLDAs from Applied Biosystem) or RNA-seq (Illumina, Ion Torrent).
- Genotyping and DNA copy number variation studies using microarrays (Affymetrix) or DNA sequencing (Illumina).
- Characterization of alternative splicing from data obtained in microarray experiments (Affymetrix) or RNA-seq (Illumina).
- Protein-DNA interactions from immuprecipitation and microarray experiments (ChIP-chip) or sequencing (ChIP-seq).
DNA methylation patterns in microarray experiments (Illumina Infinium).
Meet the research team
Scientific activity of the Bioinformatics Platform
Latest scientific publications
- Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer Aug 13, 2025 | Magazine: Signal Transduction and Targeted Therapy
- Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas Jul 15, 2025 | Magazine: Cell Reports Medicine
- Lamc2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth Jan 6, 2023 | Magazine: Clinical Cancer Research
- Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma Jun 30, 2022 | Magazine: New England of Medicine