Immunogenetic characterization of clonal plasma cells in systemic light-chain amyloidosis
Isabel Cuenca, Daniel Alameda, Beatriz Sanchez-Vega, David Gomez-Sanchez, Diego Alignani, Marta Lasa, Esther Onecha, Ramon Lecumberri, Felipe Prosper, Enrique M Ocio, Maria Esther González, Alfonso García de Coca, Javier De La Rubia, Mercedes Gironella, Luis Palomera, Albert Oriol, Maria Casanova, Valentin Cabañas, Francisco Taboada, Albert Pérez-Montaña, Felipe De Arriba, Noemi Puig, Gonzalo Carreño-Tarragona, Santiago Barrio, Jose Enrique de la Puerta, Angel Ramirez-Payer, Isabel Krsnik, Juan Jose Bargay, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus F San-Miguel, Bruno Paiva, Joaquin Martinez-Lopez
To the Editor:
Sequence-based analysis has come to play an integral role in many hematological malignancies , but disorders such as systemic light-chain (AL) amyloidosis remain poorly characterized due to its low incidence and small tumor size [2, 3].
Thus, greater knowledge about the immunogenetic landscape of AL amyloidosis is required since, for example, potential differences between the genomic profiles of AL amyloidosis and multiple myeloma (MM) could help identifying patients with monoclonal gammopathies at greater risk of developing AL amyloidosis and monitor presymptomatic organ damage [4, 5].