The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis. Scientific Publication

Nov 20, 2023 | Magazine: Oncoimmunology

Ángela Bella 1 2 , Ignacio Melero 1 2 3 4 5 , Pedro Berraondo 1 2 3 , Fernando Aranda 1 2

Abstract

Our recent research has unveiled the potential of locoregional immunotherapy. Cytokine-armored viral vectors, such as modified vaccinia virus Ankara vector encoding single-chain interleukin-12 (MVA.scIL-12), can target the omentum and elicit a robust tumor-specific immune response, all the while minimizing toxicity.

CITATION Oncoimmunology. 2023 Nov 20;12(1):2285106. doi: 10.1080/2162402X.2023.2285106. eCollection 2023.

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Our authors

Imagen del Dr. Ignacio Melero Bermejo, especialista en Inmunología de la Clínica Universidad de Navarra.

Dr. Ignacio Melero Bermejo Curriculum

Researcher | Principal Investigator Combination Strategies for Translational Immunotherapy Research Group

Dr. Fernando Aranda Vega Curriculum

Researcher | Principal Investigator Research Group on Locoregional Immunotherapy Strategies in Peritoneal Carcinomatosis

Dr. Pedro Berraondo López Curriculum

Researcher | Principal Investigator Cytokine-Based Therapeutics Research Group