Publicaciones científicas

Biological Characterization and Clinical Relevance of Circulating Tumor Cells: Opening the Pandora's Box of Multiple Myeloma

10-mar-2022 | Revista: Cancers

Juan-José Garcés  1 , Jesús San-Miguel  1 , Bruno Paiva  1


Bone marrow (BM) aspirates are the gold standard for patient prognostication and genetic characterization in multiple myeloma (MM). However, they represent an important limitation for periodic disease monitoring because they entail an aggressive procedure.

Moreover, recent findings show that a single BM aspirate is unable to reflect the complex MM heterogeneity. Recent advances in flow cytometry, microfluidics, and "omics" technologies have opened Pandora's box of MM: The detection and isolation of circulating tumor cells (CTCs) offer a promising and minimally invasive alternative for tumor assessment and metastasis study.

CTCs are detectable in premalignant and active MM states, and their enumeration has strong prognostic value, to the extent that it is challenging current stratification systems. In addition, CTCs reflect with high precision both intra- and extra-medullary disease at the phenotypic, genomic, and transcriptomic levels.

Despite this high resemblance between tumor clones in distinct locations, some subtle (not random) differences might shed some light on the metastatic process. Thus, it has been suggested that a hypoxic and pro-inflammatory microenvironment could induce an arrest in proliferation forcing tumor cells to recirculate.

Herein, we summarize data on the characterization of MM CTCs as well as their clinical and research potential.

CITA DEL ARTÍCULO  Cancers (Basel). 2022 Mar 10;14(6):1430.  doi: 10.3390/cancers14061430

Nuestros autores

Graduado adscrito al proyecto del Grupo de Mieloma Múltiple del Cima Universidad de Navarra
Juan José Garcés Latre
Graduado Adscrito a Proyecto Grupo de Investigación en Mieloma Múltiple